Objective measures of disordered sleep in fibromyalgia.
Objective measures of disordered sleep in fibromyalgia.
复制标题
DOI：
10.3899/jrheum.090051
复制
发表时间：
2009-09
期刊：
影响因子：
--
通讯作者：
Crofford LJ
中科院分区：
文献类型：
--
作者：
Chervin RD;Teodorescu M;Kushwaha R;Deline AM;Brucksch CB;Ribbens-Grimm C;Ruzicka DL;Stein PK;Clauw DJ;Crofford LJ
纤维肌痛综合征 (FMS) 患者抱怨睡眠不足，这可能会导致常见症状，包括嗜睡、疲劳或疼痛。然而，一致且客观地区分 FMS 患者的措施仍然难以捉摸。 15 名患有 FMS 的女性和 15 名年龄和性别匹配的对照者接受了 3 晚的多导睡眠图检查；多次睡眠潜伏期测试以评估困倦程度；测试非快速眼动睡眠第 2 阶段和第 4 阶段睡眠期间的听觉唤醒阈值；隔夜评估尿液游离皮质醇；以及24小时心率变异性分析。在多导睡眠图的第二天晚上，与对照组相比，患有 FMS 的女性表现出更多的阶段变化 (p=0.04)，但在任何其他标准多导睡眠图测量或多次睡眠潜伏期测试上没有显着差异。深度非快速眼动睡眠期间的阿尔法脑电图功率，单独或作为剩余睡眠阶段阿尔法功率的一部分，也无法区分各组，听觉唤醒阈值也是如此。 FMS 和对照受试者之间的尿液游离皮质醇没有一致的差异。然而，FMS 受试者的短期心率变异性下降，尤其是基于比率的 HRV 下降，分别表明副交感神经活动减弱，交感神经活动增强。其他 HRV 测量表明 FMS 受试者的 HRV 复杂性降低。睡眠的标准测量、困倦的黄金标准测量、量化的 α-δ 脑电图功率、听觉唤醒阈值和尿游离皮质醇在很大程度上无法区分 FMS 和对照受试者。然而，HRV 分析显示出更多的希望，因为它们表明 FMS 中交感神经活动增加，自主神经系统功能复杂性降低。
Patients with fibromyalgia syndrome (FMS) complain of inadequate sleep, which could contribute to common symptoms including sleepiness, fatigue, or pain. However, measures that consistently and objectively distinguish FMS patients remain elusive. Fifteen women with FMS and 15 age- and gender-matched controls underwent 3 nights of polysomnography; Multiple Sleep Latency Tests to assess sleepiness; testing of auditory arousal thresholds during non-REM stage 2 and stage 4 sleep; overnight assessment of urinary free-cortisol; and analysis of 24-hour heart rate variability. On the second night of polysomnography, women with FMS in comparison to controls showed more stage shifts (p=0.04) but did not differ significantly on any other standard polysomnographic measure or on the Multiple Sleep Latency Tests. Alpha EEG power during deep non-REM sleep, alone or as a proportion of alpha power during remaining sleep stages, also failed to distinguish the groups, as did auditory arousal thresholds. Urinary free cortisol did not differ between FMS and control subjects in a consistent manner. However, decreased short-term heart rate variability and especially ratio-based HRV among FMS subjects suggested diminished parasympathetic and increased sympathetic activity, respectively. Other HRV measures suggested decreased complexity of HRV among the FMS subjects. Standard measures of sleep, a gold-standard measure of sleepiness, quantified alpha-delta EEG power, auditory arousal thresholds, and urinary free cortisol largely failed to distinguish FMS and control subjects. However, HRV analyses showed more promise, as they suggested both increased sympathetic activity and decreased complexity of autonomic nervous system function in FMS.
登录
查看更多内容
影响因子：
--
作者：
Harris, RE;Williams, DA;Clauw, DJ
通讯作者：
Clauw, DJ
影响因子：
7.4
作者：
GRACELY, RH;KWILOSZ, DM
通讯作者：
KWILOSZ, DM
影响因子：
5.9
作者：
Lario, BA;Valdivielso, JLA;Cabello, AM
通讯作者：
Cabello, AM
影响因子：
--
作者：
CARETTE, S;OAKSON, G;STERIADE, M
通讯作者：
STERIADE, M
影响因子：
--
作者：
AKSELROD, S;GORDON, D;COHEN, RJ
通讯作者：
COHEN, RJ