A show of Hands: Novel and conserved expression patterns of teleost hand paralogs during craniofacial, heart, fin, peripheral nervous system and gut development.
A show of Hands: Novel and conserved expression patterns of teleost hand paralogs during craniofacial, heart, fin, peripheral nervous system and gut development.
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DOI：
10.1002/dvdy.380
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发表时间：
2021-12
期刊：
影响因子：
--
通讯作者：
Le Pabic P
中科院分区：
文献类型：
--
作者：
Reynolds S;Pierce C;Powell B;Kite A;Hall-Ruiz N;Schilling T;Le Pabic P
手基因是脊椎动物颌骨、心脏、周围神经系统、四肢、肠道、胎盘和蜕膜发育所必需的。两个Hand旁系同源物，Hand 1和Hand 2，存在于大多数脊椎动物中，它们介导不同的功能，但在表达上重叠。在鳍鱼中，Hand基因的表达和功能仅在斑马鱼中已知，这代表了具有单个Hand基因（hand2）的罕见情况。在这里，我们描述的手1和手2在慈鲷Copadichromis azureus的发育表达。Hand 1和Hand 2在慈鲷心脏、成对鳍、咽弓、外周神经系统、肠和侧板中胚层中表达，具有不同程度的重叠。手基因在肠道、周围神经系统和咽弓中的表达可能已经在叶鳍鱼和辐鳍鱼的共同祖先中固定下来。在其他胚胎区域，如成对的附肢，手2的表达是固定的，而手1的表达在叶鳍和鳍鱼谱系分歧。在侧板中胚层和弓相关的儿茶酚胺能细胞，手1和手2交换表达之间的分歧谱系。慈鲷hand 1和hand 2在发育中心脏的心外膜和心肌中的独特表达可能代表了硬骨鱼的祖先模式。
Hand genes are required for the development of the vertebrate jaw, heart, peripheral nervous system, limb, gut, placenta, and decidua. Two Hand paralogues, Hand1 and Hand2, are present in most vertebrates, where they mediate different functions yet overlap in expression. In ray-finned fishes, Hand gene expression and function is only known for the zebrafish, which represents the rare condition of having a single Hand gene, hand2. Here we describe the developmental expression of hand1 and hand2 in the cichlid Copadichromis azureus. hand1 and hand2 are expressed in the cichlid heart, paired fins, pharyngeal arches, peripheral nervous system, gut, and lateral plate mesoderm with different degrees of overlap. Hand gene expression in the gut, peripheral nervous system, and pharyngeal arches may have already been fixed in the lobe- and ray-finned fish common ancestor. In other embryonic regions, such as paired appendages, hand2 expression was fixed, while hand1 expression diverged in lobe- and ray-finned fish lineages. In the lateral plate mesoderm and arch associated catecholaminergic cells, hand1 and hand2 swapped expression between divergent lineages. Distinct expression of cichlid hand1 and hand2 in the epicardium and myocardium of the developing heart may represent the ancestral pattern for bony fishes.
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影响因子：
64.8
作者：
Freitas, Renata;Zhang, GuangJun;Cohn, Martin J.
通讯作者：
Cohn, Martin J.
DOI：
10.1073/pnas.1634991100
发表时间：
2003-09-30
影响因子：
11.1
作者：
Davidson, B;Levine, M
通讯作者：
Levine, M
影响因子：
2.7
作者：
CSERJESI, P;BROWN, D;OLSON, EN
通讯作者：
OLSON, EN
影响因子：
2.5
作者：
KIMMEL, CB;BALLARD, WW;SCHILLING, TF
通讯作者：
SCHILLING, TF
影响因子：
2.7
作者：
Barbosa, Ana C.;Funato, Noriko;Yanagisawa, Hiromi
通讯作者：
Yanagisawa, Hiromi