Differentiation of Malignant and Benign Head and Neck Tumors with Amide Proton Transfer-Weighted MR Imaging.
Differentiation of Malignant and Benign Head and Neck Tumors with Amide Proton Transfer-Weighted MR Imaging.
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酰胺质子转移加权 MR 成像区分恶性和良性头颈肿瘤
DOI：
10.1007/s11307-018-1248-1
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发表时间：
2019-04
影响因子：
3.1
通讯作者：
Chen M
中科院分区：
文献类型：
--
作者：
Yu L;Li C;Luo X;Zhou J;Zhang C;Zhang Y;Chen M
前瞻性评估酰胺质子转移加权 (APTw) 成像用于表征头颈部肿瘤的可行性和能力。连续 29 名疑似头颈部肿瘤的患者被纳入这项研究，并在 3.0 T MRI 扫描仪上接受了 APTw 磁共振成像 (MRI)。根据病理结果将患者分为恶性组（n = 16）和良性组（n = 13）。为每位患者生成 3.5 ppm [MTRasym(3.5 ppm)] 处的磁化传递比不对称图。评估观察者间的一致性，并对恶性组和良性组之间的 MTRasym（3.5 ppm）进行比较。接受者操作特征分析用于确定MTRasym（3.5 ppm）用于区分恶性和良性肿瘤的适当阈值。恶性组和良性组的组内相关系数分别为0.96和0.90，这表明观察者间具有良好的一致性。恶性组的MTRasym（3.5 ppm）（3.66±1.15％）显着高于良性组（1.94±0.93％，P <0.001）。 APTw MRI 显示区分这两组的曲线下面积为 0.904，灵敏度为 81.3%，特异性为 92.3%，准确度为 86.2%，阈值为 MTRasym（3.5 ppm）的 2.62%。 APTw MRI 可用于头颈部肿瘤，是区分恶性和良性病变的有价值的成像生物标志物。
To prospectively evaluate the feasibility and capability of amide proton transfer-weighted (APTw) imaging for the characterization of head and neck tumors. Twenty-nine consecutive patients with suspected head and neck tumors were enrolled in this study and underwent APTw magnetic resonance imaging (MRI) on a 3.0 T MRI scanner. The patients were divided into malignant (n = 16) and benign (n = 13) groups, based on pathological results. A map of magnetization-transfer-ratio asymmetry at 3.5 ppm [MTRasym(3.5 ppm)] was generated for each patient. Interobserver agreement was evaluated and comparisons of MTRasym(3.5 ppm) were made between the malignant and benign groups. Receiver operating characteristic analysis was used to determine the appropriate threshold value of MTRasym(3.5 ppm) for the differentiation of malignant from benign tumors. The intraclass correlation coefficients of the malignant and benign groups were 0.96 and 0.90, respectively, which indicated a good interobserver agreement. MTRasym(3.5 ppm) was significantly higher for the malignant group (3.66 ± 1.15%) than for the benign group (1.94 ± 0.93%, P < 0.001). APTw MRI revealed an area under the curve of 0.904 in discriminating these two groups, with a sensitivity of 81.3%, a specificity of 92.3%, and an accuracy of 86.2%, at the threshold of 2.62% of MTRasym(3.5 ppm). APTw MRI is feasible for use in the head and neck tumors and is a valuable imaging biomarker for distinguishing malignant from benign lesions.
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DOI：
10.1016/j.mric.2015.08.011
发表时间：
2016-02
影响因子：
1.6
作者：
Jansen JFA;Parra C;Lu Y;Shukla-Dave A
通讯作者：
Shukla-Dave A
酰胺质子转移加权 MRI 评估脑缺血的演变
影响因子：
3.4
作者：
Song G;Li C;Luo X;Zhao X;Zhang S;Zhang Y;Jiang S;Wang X;Chen Y;Chen H;Gong T;Zhou J;Chen M
通讯作者：
Chen M
影响因子：
3.3
作者：
Zhang S;Seiler S;Wang X;Madhuranthakam AJ;Keupp J;Knippa EE;Lenkinski RE;Vinogradov E
通讯作者：
Vinogradov E
影响因子：
2.2
作者：
Ward, KM;Aletras, AH;Balaban, RS
通讯作者：
Balaban, RS
影响因子：
1.3
作者：
Razek, Ahmed Abdel Khalek Abdel;Samir, Sieza;Ashmalla, Germeen Albair
通讯作者：
Ashmalla, Germeen Albair