Non-steroidal anti-inflammatory drugs and cancer risk in women: results from the Women's Health Initiative.
Non-steroidal anti-inflammatory drugs and cancer risk in women: results from the Women's Health Initiative.
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DOI：
10.1002/ijc.28823
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发表时间：
2014-10-15
影响因子：
6.4
通讯作者：
Wactawski-Wende J
中科院分区：
文献类型：
--
作者：
Brasky TM;Liu J;White E;Peters U;Potter JD;Walter RB;Baik CS;Lane DS;Manson JE;Vitolins MZ;Allison MA;Tang JY;Wactawski-Wende J
在一些研究中，非甾体抗炎药（NSAID）的使用与几个部位的癌症风险降低相关;然而，我们最近在一项前瞻性研究中报告了其使用与女性总癌症风险之间的相关性。在这里，我们研究了非甾体抗炎药和总的和特定部位的癌症发病率之间的关系，在大型，前瞻性的妇女健康倡议（WHI）。从1993年到1998年，在美国40个临床中心招募了129,013名妇女参加WHI，并进行了前瞻性随访。经过9.7年的随访，诊断出12，998例原发性浸润性癌症。在研究访视时系统收集NSAID使用情况。我们使用考克斯比例风险回归模型来估计非甾体抗炎药使用与总体和部位特异性癌症风险之间的关联的多变量调整风险比（HR）和95%置信区间（CI）。相对于不使用，持续使用（即，基线和随访第3年使用任何NSAID与总癌症风险无关（HR 1.00，95% CI：0.94-1.06）。单个NSAID的结果与总体测量结果相似。在特定研究中心的分析中，NSAID与结直肠癌、卵巢癌和黑色素瘤的风险降低相关。我们的研究证实了女性结直肠癌的化学预防益处，并为降低某些罕见癌症的风险提供了初步证据。NSAID对癌症风险的益处仅限于特定部位，并且在检查总癌症风险时并不明显。当NSAID被认为是化学预防剂时，这一信息可能很重要。
The use of non-steroidal anti-inflammatory drugs (NSAIDs) has been associated with reduced risks of cancers at several sites in some studies; however, we recently reported no association between their use and total cancer risk in women in a prospective study. Here we examine the association between NSAIDs and total and site-specific cancer incidence in the large, prospective Women’s Health Initiative (WHI). 129,013 women were recruited to participate in the WHI at 40 US clinical centers from 1993 to 1998 and followed prospectively. After 9.7 years of follow-up, 12,998 incident, first primary, invasive cancers were diagnosed. NSAID use was systematically collected at study visits. We used Cox proportional hazards regression models to estimate multivariable-adjusted hazard ratios (HR) and 95% confidence intervals (CI) for associations between NSAIDs use and total and site-specific cancer risk. Relative to non-use, consistent use (i.e., use at baseline and year 3 of follow-up) of any NSAID was not associated with total cancer risk (HR 1.00, 95% CI: 0.94–1.06). Results for individual NSAIDs were similar to the aggregate measure. In site-specific analyses, NSAIDs were associated with reduced risks of colorectal cancer, ovarian cancer, and melanoma. Our study confirms a chemopreventive benefit for colorectal cancer in women and gives preliminary evidence for a reduction of the risk of some rarer cancers. NSAIDs’ benefit on cancer risk was limited to specific sites and not evident when total cancer risk was examined. This information may be of importance when NSAIDs are considered as chemopreventive agents.
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影响因子：
5.6
作者：
Anderson, GL;Manson, J;Prentice, RL
通讯作者：
Prentice, RL
影响因子：
5
作者：
Allison, Matthew;Garland, Cedric;Kuller, Lewis
通讯作者：
Kuller, Lewis
影响因子：
3.8
作者：
Gates, Margaret A.;Tworoger, Shelley S.;Hankinson, Susan E.
通讯作者：
Hankinson, Susan E.
影响因子：
6.4
作者：
Neill, Annette S.;Nagle, Christina M.;Webb, Penelope M.
通讯作者：
Webb, Penelope M.
影响因子：
10.3
作者：
Bardia, Aditya;Ebbert, Jon O.;Cerhan, James R.
通讯作者：
Cerhan, James R.