Age and Alzheimer's Disease-Related Oligodendrocyte Changes in Hippocampal Subregions.
Age and Alzheimer's Disease-Related Oligodendrocyte Changes in Hippocampal Subregions.
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DOI：
10.3389/fncel.2022.847097
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发表时间：
2022
影响因子：
5.3
通讯作者：
Kang, Shin H.
中科院分区：
文献类型：
--
作者：
DeFlitch, Leah;Gonzalez-Fernandez, Estibaliz;Crawley, Ilan;Kang, Shin H.
少突胶质细胞（OLs）形成髓鞘并为中枢神经系统的轴突提供代谢支持。尽管大多数OL在出生后早期发育，但OL的生成会持续到成年期，这种晚期的少突胶质形成可能有助于成年大脑的神经网络可塑性。我们使用遗传工具对OL祖细胞（OPCs）进行标记和命运追踪，从而确定正常衰老海马亚区OL种群的生长情况。OL数量增加到至少1岁，但这种OL变化的速度和程度在海马亚区之间有所不同。特别是，成体少突发生在CA3和CA4亚区最为突出。在类似阿尔茨海默病的情况下，APP/PS1小鼠的CA3和CA4中OL的损失也最为严重，尽管该疾病并未损害这些区域OPC向OL分化的速度。这种区域特异性的动态OL变化与OPCs或星形胶质细胞的变化或Aβ沉积物的区域分布无关。我们的研究结果表明，成人海马髓磷脂可塑性和疾病相关OL易感性的亚区域依赖机制。
Oligodendrocytes (OLs) form myelin sheaths and provide metabolic support to axons in the CNS. Although most OLs develop during early postnatal life, OL generation continues in adulthood, and this late oligodendrogenesis may contribute to neuronal network plasticity in the adult brain. We used genetic tools for OL labeling and fate tracing of OL progenitors (OPCs), thereby determining OL population growth in hippocampal subregions with normal aging. OL numbers increased up to at least 1 year of age, but the rates and degrees of this OL change differed among hippocampal subregions. In particular, adult oligodendrogenesis was most prominent in the CA3 and CA4 subregions. In Alzheimer’s disease-like conditions, OL loss was also most severe in the CA3 and CA4 of APP/PS1 mice, although the disease did not impair the rate of OPC differentiation into OLs in those regions. Such region-specific, dynamic OL changes were not correlated with those of OPCs or astrocytes, or the regional distribution of Aβ deposits. Our findings suggest subregion-dependent mechanisms for myelin plasticity and disease-associated OL vulnerability in the adult hippocampus.
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影响因子：
3.7
作者：
Grosche, Antje;Grosche, Jens;Reichenbach, Andreas
通讯作者：
Reichenbach, Andreas
影响因子：
17.1
作者：
Fard MK;van der Meer F;Sánchez P;Cantuti-Castelvetri L;Mandad S;Jäkel S;Fornasiero EF;Schmitt S;Ehrlich M;Starost L;Kuhlmann T;Sergiou C;Schultz V;Wrzos C;Brück W;Urlaub H;Dimou L;Stadelmann C;Simons M
通讯作者：
Simons M
影响因子：
25
作者：
Hughes EG;Orthmann-Murphy JL;Langseth AJ;Bergles DE
通讯作者：
Bergles DE
DOI：
10.1111/ejn.14726
发表时间：
2021-09
期刊：
The European journal of neuroscience
影响因子：
--
作者：
Ferreira S;Pitman KA;Summers BS;Wang S;Young KM;Cullen CL
通讯作者：
Cullen CL
影响因子：
7.7
作者：
González-Fernández E;Jeong HK;Fukaya M;Kim H;Khawaja RR;Srivastava IN;Waisman A;Son YJ;Kang SH
通讯作者：
Kang SH