The Clinical Application of Porous Tantalum and Its New Development for Bone Tissue Engineering.
The Clinical Application of Porous Tantalum and Its New Development for Bone Tissue Engineering.
复制标题
多孔钽的临床应用及其骨组织工程新进展。
DOI：
10.3390/ma14102647
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发表时间：
2021-05-18
期刊：
影响因子：
--
通讯作者：
Qiu JX
中科院分区：
文献类型：
--
作者：
Huang G;Pan ST;Qiu JX
多孔钽（Ta）是一种很有前途的生物材料，在骨科和牙科领域的应用已有近二十年的历史。多孔钽的高孔隙率和互连孔结构保证了内部空间内良好的骨长入和新骨形成，这进一步保证了快速骨整合和骨种植体的长期稳定性。多孔Ta具有高润湿性和表面能，可以促进成骨细胞的粘附、增殖和矿化。同时，多孔Ta的低弹性模量和高摩擦系数使其能够有效避免应力屏蔽效应，最大限度地减少边缘骨丢失，确保初期稳定性。因此，多孔钽基植入物或假体令人满意的临床应用主要源于其优异的生物学和机械性能。随着增材制造的出现，个性化多孔钽基植入物或假体在治疗需要专门设计的植入物或假体的个体患者方面显示出其临床价值。此外，还引入了许多修饰方法来增强多孔Ta的生物活性和抗菌性能，并在体外和体内研究中取得了良好的成果。无论如何，选择合适的患者对于保证多孔Ta植入手术的成功非常重要。
Porous tantalum (Ta) is a promising biomaterial and has been applied in orthopedics and dentistry for nearly two decades. The high porosity and interconnected pore structure of porous Ta promise fine bone ingrowth and new bone formation within the inner space, which further guarantee rapid osteointegration and bone–implant stability in the long term. Porous Ta has high wettability and surface energy that can facilitate adherence, proliferation and mineralization of osteoblasts. Meanwhile, the low elastic modulus and high friction coefficient of porous Ta allow it to effectively avoid the stress shield effect, minimize marginal bone loss and ensure primary stability. Accordingly, the satisfactory clinical application of porous Ta-based implants or prostheses is mainly derived from its excellent biological and mechanical properties. With the advent of additive manufacturing, personalized porous Ta-based implants or prostheses have shown their clinical value in the treatment of individual patients who need specially designed implants or prosthesis. In addition, many modification methods have been introduced to enhance the bioactivity and antibacterial property of porous Ta with promising in vitro and in vivo research results. In any case, choosing suitable patients is of great importance to guarantee surgical success after porous Ta insertion.
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影响因子：
1.5
作者：
Boone, David W
通讯作者：
Boone, David W
影响因子：
5.3
作者：
DeFrancesco, Christopher J.;Canseco, Jose A.;Kamath, Atul F.
通讯作者：
Kamath, Atul F.
影响因子：
11
作者：
Bandyopadhyay, Amit;Mitra, Indranath;Bose, Susmita
通讯作者：
Bose, Susmita
DOI：
10.1016/0267-6605(94)90113-9
发表时间：
1994-01-01
期刊：
Clinical Materials
影响因子：
--
作者：
Black, Jonathan
通讯作者：
Black, Jonathan
影响因子：
5.3
作者：
Barg, Alexej;Bettin, Clayton C.;Gililland, Jeremy
通讯作者：
Gililland, Jeremy