Circulating C-Peptide Levels in Living Children and Young People and Pancreatic β-Cell Loss in Pancreas Donors Across Type 1 Diabetes Disease Duration.
Circulating C-Peptide Levels in Living Children and Young People and Pancreatic β-Cell Loss in Pancreas Donors Across Type 1 Diabetes Disease Duration.
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c肽在1型糖尿病中下降，尽管许多长期患者保持低但可检测的水平。组织学分析证实β-细胞在1型糖尿病发病后仍然存在。我们研究了英国糖尿病遗传资源调查（UK GRID）队列（N = 4,079）中观察到的c肽下降趋势，糖尿病胰腺器官供体网络（nPOD）生物库和埃克塞特糖尿病档案生物库（EADB）（合并N = 235）中胰腺供体的β细胞损失，并根据最近报告的诊断年龄（<7岁，7 - 12岁，≥13岁）在糖尿病持续时间的增加中分层。诊断后一年后可检测到c肽的个体比例下降，但在最年轻的年龄组中最为明显（<1年持续时间：年龄<7岁：20人中有18人[90%]，7 - 12岁：110人中有107人[97%]，≥13岁：61人中有58人[95%]，而诊断后1-5年：<7年：522人中有172人[33%]，7 - 12年：995人中有604人[61%]，≥13年：289人中有225人[78%]）。在β细胞损失中也观察到类似的情况，年龄较小的患者含有胰岛素阳性（胰岛素+）β细胞的胰岛损失更快，诊断后<1年：年龄<7岁：26人中23人（88%），7 - 12岁：33人中32人（97%），≥13岁：25人中22人（88%），而诊断后1 - 5年：<7岁：12人中1人（8.3%），7 - 12岁：13人中7人（54%），≥13岁：8人中7人（88%）。在计划和解释旨在促进β细胞保留和功能的干预试验时应考虑这些数据。
C-peptide declines in type 1 diabetes, although many long-duration patients retain low, but detectable levels. Histological analyses confirm that β-cells can remain following type 1 diabetes onset. We explored the trends observed in C-peptide decline in the UK Genetic Resource Investigating Diabetes (UK GRID) cohort (N = 4,079), with β-cell loss in pancreas donors from the network for Pancreatic Organ donors with Diabetes (nPOD) biobank and the Exeter Archival Diabetes Biobank (EADB) (combined N = 235), stratified by recently reported age at diagnosis endotypes (<7, 7–12, ≥13 years) across increasing diabetes durations. The proportion of individuals with detectable C-peptide declined beyond the first year after diagnosis, but this was most marked in the youngest age group (<1-year duration: age <7 years: 18 of 20 [90%], 7–12 years: 107 of 110 [97%], ≥13 years: 58 of 61 [95%] vs. 1–5 years postdiagnosis: <7 years: 172 of 522 [33%], 7–12 years: 604 of 995 [61%], ≥13 years: 225 of 289 [78%]). A similar profile was observed in β-cell loss, with those diagnosed at younger ages experiencing more rapid loss of islets containing insulin-positive (insulin+) β-cells <1 year postdiagnosis: age <7 years: 23 of 26 (88%), 7–12 years: 32 of 33 (97%), ≥13 years: 22 of 25 (88%) vs. 1–5 years postdiagnosis: <7 years: 1 of 12 (8.3%), 7–12 years: 7 of 13 (54%), ≥13 years: 7 of 8 (88%). These data should be considered in the planning and interpretation of intervention trials designed to promote β-cell retention and function.
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影响因子：
30.8
作者：
Barrett, Jeffrey C.;Clayton, David G.;Concannon, Patrick;Akolkar, Beena;Cooper, Jason D.;Erlich, Henry A.;Julier, Cecile;Morahan, Grant;Nerup, Jorn;Nierras, Concepcion;Plagnol, Vincent;Pociot, Flemming;Schuilenburg, Helen;Smyth, Deborah J.;Stevens, Helen;Todd, John A.;Walker, Neil M.;Rich, Stephen S.
通讯作者：
Rich, Stephen S.
影响因子：
7.7
作者：
Leete, Pia;Willcox, Abby;Morgan, Noel G.
通讯作者：
Morgan, Noel G.
影响因子：
7.7
作者：
Keenan HA;Sun JK;Levine J;Doria A;Aiello LP;Eisenbarth G;Bonner-Weir S;King GL
通讯作者：
King GL
影响因子：
158.5
作者：
Herold, Kevan C.;Bundy, Brian N.;Greenbaum, Carla J.
通讯作者：
Greenbaum, Carla J.
影响因子：
16.2
作者：
Davis, Asa K.;DuBose, Stephanie N.;Greenbaum, Carla J.
通讯作者：
Greenbaum, Carla J.