Responses of neurologic complications of AIDS to 3'-azido-3'-deoxythymidine and 9-(1,3-dihydroxy-2-propoxymethyl) guanine. I. Clinical features.
Responses of neurologic complications of AIDS to 3'-azido-3'-deoxythymidine and 9-(1,3-dihydroxy-2-propoxymethyl) guanine. I. Clinical features.
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艾滋病神经系统并发症对 3-叠氮基-3-脱氧胸苷和 9-(1,3-二羟基-2-丙氧基甲基)鸟嘌呤的反应。
DOI：
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
W. Tourtelotte
中科院分区：
文献类型：
--
作者：
M. Fiala;L. Cone;N. Cohen;D. Patel;K. Williams;D. Casareale;P. Shapshak;W. Tourtelotte
14 名艾滋病患者因 23 种神经系统并发症而接受治疗：四次急性脑膜脑炎发作；八次亚急性脑病发作；进行性多灶性白质脑病两例；以及九例多发性神经病。 9 名患者接受了 9-(1,3-二羟基-2-丙氧基甲基)鸟嘌呤 (DHPG) 治疗，1 名患者接受了 3'-叠氮基-3'-脱氧胸苷 (AZT) 治疗，4 名患者最初使用 DHPG 治疗巨细胞病毒 (CMV) 视网膜炎或脑炎，随后使用 AZT 治疗人类免疫缺陷病毒 (HIV) 脑病。 CMV 视网膜炎是一项有用的临床观察，表明神经系统受累。 DHPG 对三例急性脑膜脑炎病例中的两例有改善作用，但对亚急性脑病或神经病病例无效。 AZT 治疗使两例急性精神错乱状态的治疗病例和四例伴有截瘫的多发性神经根神经病病例中的两例得到缓解，但对亚急性脑病晚期无效。这些结果表明，CMV 在某些急性脑膜脑炎病例中很重要，而 HIV 是 AIDS 患者亚急性痴呆和多发性神经病的主要病原体。 DHPG 可能对前者有益，而 AZT 似乎对后者并发症有效。
Fourteen patients with AIDS were treated for 23 neurologic complications: four episodes of acute meningoencephalitis; eight episodes of subacute encephalopathy; two cases of progressive multifocal leukoencephalopathy; and nine cases of polyneuropathy. Nine patients were treated with 9-(1,3-dihydroxy-2-propoxymethyl)guanine (DHPG), one with 3'-azido-3'-deoxythymidine (AZT), and four initially with DHPG directed against cytomegalovirus (CMV) retinitis or encephalitis and subsequently with AZT against human immunodeficiency virus (HIV) encephalopathy. CMV retinitis was a helpful clinical observation indicating neurologic involvement. DHPG produced improvement in two of three cases of acute meningoencephalitis but was ineffective in cases of subacute encephalopathy or neuropathy. AZT therapy resulted in resolution in both of the two treated cases of acute confusional state and in two of the four treated cases of polyradiculoneuropathy with paraparesis but was ineffective in the late stage of subacute encephalopathy. These results suggest that CMV is important in some cases of acute meningoencephalitis, whereas HIV is a dominant pathogen in subacute dementia and polyneuropathy in patients with AIDS. DHPG may be beneficial in the former, whereas AZT appears to be effective in the latter complications.
绵羊和山羊的慢病毒病：慢性肺炎、白质脑脊髓炎和关节炎。
DOI：
10.1093/clinids/7.1.89
发表时间：
1985
期刊：
Reviews of infectious diseases
影响因子：
--
作者：
Narayan,O;Cork,LC
通讯作者：
Cork,LC
一种能够抵抗人类免疫缺陷病毒 (HIV) 细胞病变效应的人类 T 细胞系。
影响因子：
3.7
作者：
Casareale,D;Stevenson,M;Sakai,K;Volsky,DJ
通讯作者：
Volsky,DJ
DOI：
10.1073/pnas.83.18.7089
发表时间：
1986-09-01
影响因子：
11.1
作者：
WILEY, CA;SCHRIER, RD;OLDSTONE, MBA
通讯作者：
OLDSTONE, MBA