Association between pre-diagnostic leukocyte mitochondrial DNA copy number and survival among colorectal cancer patients.
Association between pre-diagnostic leukocyte mitochondrial DNA copy number and survival among colorectal cancer patients.
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DOI：
10.1016/j.canep.2020.101778
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发表时间：
2020-10
影响因子：
2.6
通讯作者：
Nan H
中科院分区：
文献类型：
--
作者：
Yang K;Forman MR;Graham BH;Monahan PO;Giovannucci EL;De Vivo I;Chan AT;Nan H
线粒体DNA拷贝数（mtDNAcn）被认为是线粒体功能和氧化应激的生物标志物。虽然以前的研究表明，在结直肠癌（CRC）诊断和CRC预后时的mtDNA之间存在潜在的关系，但结果并不一致，并且没有研究专门研究诊断前mtDNA与CRC生存率的关系。我们在护士健康研究和卫生专业人员随访研究中检查了587例患者诊断前白细胞mtDNAAcn（通过qPCR测量）与总体和CRC特异性生存率的相关性。构建考克斯模型以估计风险比（HR）和95%置信区间（95% CI）。在平均10.5年的随访中，确定了395例死亡; 180例死于CRC。总的来说，我们没有观察到mtDNAc与所有病例或癌症部位、级别或分期的总体或CRC特异性生存率之间的显著相关性。在一项探索性分层分析中，提示目前吸烟者中mtDNAn与总体死亡风险呈负相关[mtDNAn降低1 SD的HR（95%CI）= 1.50（0.98，2.32），P趋势=0.06]。在诊断时年龄≤ 70.5岁的患者中观察到mtDNAn降低和CRC特异性死亡风险降低[mtDNAn降低1 SD的HR（95% CI）= 0.71（0.52，0.97），P趋势= 0.03]，从采血到诊断≤ 5年[mtDNAn降低1个SD的HR（95% CI）= 0.65（0.44，0.96），P趋势= 0.03]和那些消耗低炎症饮食的人[mtDNAn降低1 SD的HR（95%CI）= 0.61（0.42，0.88），P趋势= 0.009]。在诊断前白细胞mtDNAc n与总生存率或CRC特异性生存率之间没有显著关联，但探索性分析确定了潜在的亚组关联。
Mitochondrial DNA copy number (mtDNAcn) is considered a biomarker for mitochondrial function and oxidative stress. Although previous studies have suggested a potential relationship between mtDNAcn at the time of colorectal cancer (CRC) diagnosis and CRC prognosis, findings have been inconsistent, and no study has specifically investigated the association of pre-diagnostic mtDNAcn with CRC survival. We examined the association of pre-diagnostic leukocyte mtDNAcn (measured by qPCR) with overall and CRC-specific survival among 587 patients in Nurses’ Health Study and Health Professionals Follow-Up Study. Cox models were constructed to estimate hazard ratios (HRs) and 95% confidence intervals (95% CIs). During a mean follow-up of 10.5 years, 395 deaths were identified; 180 were due to CRC. Overall, we did not observe significant associations between mtDNAcn and either overall or CRC-specific survival among all cases or by cancer location, grade, or stage. In an exploratory stratified analysis, a suggestive inverse association of mtDNAcn and overall death risk appeared among current smokers [HR (95% CI) for 1 SD decrease in mtDNAcn = 1.50 (0.98, 2.32), P-trend=0.06]. Reduced mtDNAcn and lower CRC-specific death risk was observed among patients aged ≤ 70.5 at diagnosis [HR (95% CI) for 1 SD decrease of mtDNAcn = 0.71 (0.52, 0.97), P-trend = 0.03], ≤ 5 years from blood collection to diagnosis [HR (95% CI) for 1 SD decrease in mtDNAcn = 0.65 (0.44, 0.96), P-trend = 0.03] and those consuming a low-inflammatory diet [HR (95% CI) for 1 SD decrease in mtDNAcn = 0.61 (0.42, 0.88), P-trend = 0.009]. no significant associations between pre-diagnostic leukocyte mtDNAcn and either overall or CRC-specific survival appeared but exploratory analysis identified potential sub-group associations.
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DOI：
10.1158/1055-9965.epi-14-0297
发表时间：
2014-11
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
Huang B;Gao YT;Shu XO;Wen W;Yang G;Li G;Courtney R;Ji BT;Li HL;Purdue MP;Zheng W;Cai Q
通讯作者：
Cai Q
影响因子：
3.8
作者：
Cui H;Huang P;Wang Z;Zhang Y;Zhang Z;Xu W;Wang X;Han Y;Guo X
通讯作者：
Guo X
影响因子：
6.2
作者：
Qu, Falin;Liu, Xiaonan;Xing, Jinliang
通讯作者：
Xing, Jinliang
影响因子：
5.3
作者：
Mengel-From, Jonas;Thinggaard, Mikael;Dalgard, Christine;Kyvik, Kirsten Ohm;Christensen, Kaare;Christiansen, Lene
通讯作者：
Christiansen, Lene
影响因子：
--
作者：
Meng, Shasha;Wu, Shaowei;Nan, Hongmei
通讯作者：
Nan, Hongmei