Sequential stages and distribution patterns of aging-related tau astrogliopathy (ARTAG) in the human brain.
Sequential stages and distribution patterns of aging-related tau astrogliopathy (ARTAG) in the human brain.
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DOI：
10.1186/s40478-018-0552-y
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发表时间：
2018-06-11
影响因子：
7.1
通讯作者：
Trojanowski JQ
中科院分区：
文献类型：
--
作者：
Kovacs GG;Xie SX;Robinson JL;Lee EB;Smith DH;Schuck T;Lee VM;Trojanowski JQ
衰老相关的tau星形胶质病(ARTAG)描述了不同部位和解剖区域星形胶质细胞的tau病理改变。在本研究中，我们讨论了在原发性FTLD-tau病和非FTLD-tau病病例中，是否可以识别ARTAG或星形胶质tau病理的序贯分布模式。通过评估687例患有不同疾病的死后大脑，我们确定了455例ARTAG。我们评估了解剖受累的频率和等级聚集，并使用条件概率和Logistic回归来模拟ARTAG和星形胶质细胞tau病理在不同脑区的顺序分布。对于软膜下和白质ARTAG，我们分别识别出三种和两种模式，每种模式都有三个阶段开始或结束于杏仁核。室管膜下ARTAG未显示清晰的序列模式。对于灰质(GM)ARTAG，我们识别了四个阶段，包括纹状体路径向皮质和/或杏仁核和脑干扩散，以及杏仁核路径，它在纹状体和/或皮质受累之前向脑干扩散。皮质基底性变性的GM ARTAG和星形细胞斑块病理主要遵循额顶叶皮质到颞枕皮质、皮质下和脑干通路(四个阶段)。进行性核上性瘫痪的GM-ARTAG和星形胶质细胞簇状病理表现为纹状体-额顶皮质-颞叶-枕叶-杏仁核-脑干序列(四期)。在具有星形胶质细胞tau病理的Pick病病例中，可以理解PSP与PSP的重叠模式。我们的结论是，tau-星形胶质病型特异性序列模式不能简化为基于神经元的分期系统。所提出的细胞病理学和分级阶段提供了一种概念性的方法，以确定ARTAG和原发性FTLD-tauopathy中tau病理的最初发病步骤。本文的在线版本(10.1186/s40478-0180552-y)包含补充材料，可供授权用户使用。
Aging-related tau astrogliopathy (ARTAG) describes tau pathology in astrocytes in different locations and anatomical regions. In the present study we addressed the question of whether sequential distribution patterns can be recognized for ARTAG or astroglial tau pathologies in both primary FTLD-tauopathies and non-FTLD-tauopathy cases. By evaluating 687 postmortem brains with diverse disorders we identified ARTAG in 455. We evaluated frequencies and hierarchical clustering of anatomical involvement and used conditional probability and logistic regression to model the sequential distribution of ARTAG and astroglial tau pathologies across different brain regions. For subpial and white matter ARTAG we recognize three and two patterns, respectively, each with three stages initiated or ending in the amygdala. Subependymal ARTAG does not show a clear sequential pattern. For grey matter (GM) ARTAG we recognize four stages including a striatal pathway of spreading towards the cortex and/or amygdala, and the brainstem, and an amygdala pathway, which precedes the involvement of the striatum and/or cortex and proceeds towards the brainstem. GM ARTAG and astrocytic plaque pathology in corticobasal degeneration follows a predominantly frontal-parietal cortical to temporal-occipital cortical, to subcortical, to brainstem pathway (four stages). GM ARTAG and tufted astrocyte pathology in progressive supranuclear palsy shows a striatum to frontal-parietal cortical to temporal to occipital, to amygdala, and to brainstem sequence (four stages). In Pick’s disease cases with astroglial tau pathology an overlapping pattern with PSP can be appreciated. We conclude that tau-astrogliopathy type-specific sequential patterns cannot be simplified as neuron-based staging systems. The proposed cytopathological and hierarchical stages provide a conceptual approach to identify the initial steps of the pathogenesis of tau pathologies in ARTAG and primary FTLD-tauopathies. The online version of this article (10.1186/s40478-018-0552-y) contains supplementary material, which is available to authorized users.
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影响因子：
4.1
作者：
Josephs, KA;Mandrekar, JN;Dickson, DW
通讯作者：
Dickson, DW
影响因子：
12.7
作者：
Kovacs GG;Ferrer I;Grinberg LT;Alafuzoff I;Attems J;Budka H;Cairns NJ;Crary JF;Duyckaerts C;Ghetti B;Halliday GM;Ironside JW;Love S;Mackenzie IR;Munoz DG;Murray ME;Nelson PT;Takahashi H;Trojanowski JQ;Ansorge O;Arzberger T;Baborie A;Beach TG;Bieniek KF;Bigio EH;Bodi I;Dugger BN;Feany M;Gelpi E;Gentleman SM;Giaccone G;Hatanpaa KJ;Heale R;Hof PR;Hofer M;Hortobágyi T;Jellinger K;Jicha GA;Ince P;Kofler J;Kövari E;Kril JJ;Mann DM;Matej R;McKee AC;McLean C;Milenkovic I;Montine TJ;Murayama S;Lee EB;Rahimi J;Rodriguez RD;Rozemüller A;Schneider JA;Schultz C;Seeley W;Seilhean D;Smith C;Tagliavini F;Takao M;Thal DR;Toledo JB;Tolnay M;Troncoso JC;Vinters HV;Weis S;Wharton SB;White CL 3rd;Wisniewski T;Woulfe JM;Yamada M;Dickson DW
通讯作者：
Dickson DW
影响因子：
5.3
作者：
Forman, MS;Lal, D;Trojanowski, JQ
通讯作者：
Trojanowski, JQ
影响因子：
12.7
作者：
Josephs KA;Murray ME;Whitwell JL;Tosakulwong N;Weigand SD;Petrucelli L;Liesinger AM;Petersen RC;Parisi JE;Dickson DW
通讯作者：
Dickson DW
影响因子：
12.7
作者：
Botez, G;Probst, A;Tolnay, M
通讯作者：
Tolnay, M