Visible light and near-infrared-responsive chromophores for drug delivery-on-demand applications.
Visible light and near-infrared-responsive chromophores for drug delivery-on-demand applications.
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DOI：
10.1007/s13346-015-0260-0
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发表时间：
2015-12
影响因子：
5.4
通讯作者：
Wu, Benjamin M.
中科院分区：
文献类型：
--
作者：
Linsley, Chase S.;Quach, Viola Y.;Agrawal, Gaurav;Hartnett, Elyse;Wu, Benjamin M.
关键词：
对生物活性分子释放的时空控制的需要促使人们努力设计通过光照射驱动的新型药物按需递送策略。然而，由于光响应部分或光波长、强度和持续时间的生物相容性问题，许多系统仅限于体外概念验证。为了克服这些局限性，本文描述了一种光致药物按需递送策略，该策略使用可见光和近红外（NIR）光以及生物相容性发色团：心绿素、亚甲蓝和核黄素。所有3种发色团在暴露于NIR和可见光时都能够发生显著的光热反应，并且温度变化的量取决于光强度、波长以及发色团浓度。牛血清白蛋白（BSA）从热响应性水凝胶脉冲释放超过4天。这些发现有可能将光致药物按需递送系统从实验室转化为需要明确控制生物活性分子呈现的临床应用。
The need for temporal-spatial control over the release of biologically active molecules has motivated efforts to engineer novel drug delivery-on-demand strategies actuated via light irradiation. Many systems, however, have been limited to in vitro proof-of-concept due to biocompatibility issues with the photo-responsive moieties or the light wavelength, intensity and duration. To overcome these limitations, this paper describes a light actuated drug delivery-on-demand strategy that uses visible and near infrared (NIR) light and biocompatible chromophores: cardiogreen, methylene blue and riboflavin. All 3 chromophores are capable of significant photothermal reaction upon exposure to NIR and visible light, and the amount of temperature change is dependent upon light intensity, wavelength as well as chromophore concentration. Pulsatile release of bovine serum albumin (BSA) from thermally-responsive hydrogels was achieved over 4 days. These findings have the potential to translate light actuated drug delivery-on-demand systems from the bench to clinical applications that require explicit control over the presentation of biologically active molecules.
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影响因子：
--
作者：
BERGMANN, K;OKONSKI, CT
通讯作者：
OKONSKI, CT
DOI：
10.1073/pnas.1114551109
发表时间：
2012-05-29
影响因子：
11.1
作者：
Jayakumar, Muthu Kumara Gnanasammandhan;Idris, Niagara Muhammad;Zhang, Yong
通讯作者：
Zhang, Yong
影响因子：
16.6
作者：
Carter, Kevin A.;Shao, Shuai;Hoopes, Matthew I.;Luo, Dandan;Ahsan, Bilal;Grigoryants, Vladimir M.;Song, Wentao;Huang, Haoyuan;Zhang, Guojian;Pandey, Ravindra K.;Geng, Jumin;Pfeifer, Blaine A.;Scholes, Charles P.;Ortega, Joaquin;Karttunen, Mikko;Lovell, Jonathan F.
通讯作者：
Lovell, Jonathan F.
影响因子：
3.7
作者：
Kim, Tae Hee;Chen, Yongping;Pun, Suzie H.
通讯作者：
Pun, Suzie H.
影响因子：
4.6
作者：
Hah, Hoe Jin;Kim, Gwangseong;Kopelman, Raoul
通讯作者：
Kopelman, Raoul