Trends in childhood rhabdomyosarcoma incidence and survival in the United States, 1975-2005.
Trends in childhood rhabdomyosarcoma incidence and survival in the United States, 1975-2005.
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DOI：
10.1002/cncr.24465
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发表时间：
2009-09-15
期刊：
影响因子：
6.2
通讯作者：
Ross, Julie A.
中科院分区：
文献类型：
--
作者：
Ognjanovic, Simona;Linabery, Amy M.;Charbonneau, Bridget;Ross, Julie A.
横纹肌肉瘤（RMS）是最常见的软组织肉瘤的儿童和青少年年龄<20岁，其病因仍然在很大程度上不明。胚胎型（ERMS）和腺泡型横纹肌肉瘤（ARMS）是最常见的亚型，被认为通过不同的生物学机制产生。我们评估了RMS人口统计学亚组的发病率和生存趋势，为未来的病因学假设提供信息。使用来自监测、流行病学和最终结果项目的数据分析了20岁以下儿童和青少年RMS的发病率和生存趋势。计算频率、年龄校正的发病率和生存率以及联合点回归结果，包括年变化百分比（APC）和95%置信区间（CI）。1975 ~ 2005年ERMS发病率稳定，ARMS发病率显著上升（APC= 4.20%，95%CI=2.60%~ 5.82%）。这种趋势可能部分归因于诊断的变化，因为同时观察到RMS的显著负趋势，未另行说明。观察到ERMS的双峰年龄峰，仅在男性中观察到青春期的第二个较小的峰; ARMS发生率不随年龄或性别而变化。RMS和ERMS的5年生存率从1976-1980年（分别为52.7%和60.9%）增加到1996-2000年（分别为61.8%和73.4%），而ARMS几乎没有改善（分别为40.1%和47.8%）。观察到的两种主要RMS亚型在性别和年龄亚组中的发病率和生存率差异进一步支持了这些肿瘤独特的潜在病因。探索这些差异提供了一个机会，以增加我们的RMS知识。
Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children and adolescents aged <20 years; its etiology remains largely unknown. Embryonal (ERMS) and alveolar rhabdomyosarcoma (ARMS), the most common subtypes, are thought to arise through distinct biological mechanisms. We evaluated incidence and survival trends by RMS demographic subgroups to inform future etiologic hypotheses. Incidence and survival trends in RMS among children and adolescents aged <20 years were analyzed using data from the Surveillance, Epidemiology and End Results Program. Frequencies, age-adjusted incidence and survival rates, and jointpoint regression results, including annual percent change (APC) and 95% confidence intervals (CI), were calculated. Between 1975 and 2005, the incidence of ERMS was stable, while a significant increase in the incidence of ARMS was observed (APC=4.20%, 95%CI=2.60%–5.82%). This trend may be partially attributable to shifts in diagnosis, as a significant negative trend in RMS, not otherwise specified was observed concurrently. A bimodal age peak for ERMS was observed, with the second, smaller peak in adolescence noted for males only; ARMS incidence did not vary by age or sex. Five-year survival rates for RMS and ERMS increased from the period 1976–1980 (52.7% and 60.9%, respectively) to 1996–2000 (61.8% and 73.4%, respectively), while there was little improvement for ARMS (40.1% and 47.8%, respectively). Observed differences in incidence and survival for two major RMS subtypes across gender and age subgroups further support unique underlying etiologies for these tumors. Exploration of these differences presents an opportunity to increase our knowledge of RMS.
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影响因子：
1.9
作者：
BROWN, CC
通讯作者：
BROWN, CC
影响因子：
11.2
作者：
Davicioni, Elai;Finckenstein, Friedrich Graf;Anderson, Michael J.
通讯作者：
Anderson, Michael J.
影响因子：
56.9
作者：
MALKIN, D;LI, FP;FRIEND, SH
通讯作者：
FRIEND, SH
影响因子：
8.8
作者：
HARTLEY, AL;BIRCH, JM;WATERHOUSE, JAH
通讯作者：
WATERHOUSE, JAH
影响因子：
6.2
作者：
Linabery, Amy M.;Ross, Julie A.
通讯作者：
Ross, Julie A.