Role of the ghrelin system in alcohol use disorder and alcohol-associated liver disease: A narrative review.
Role of the ghrelin system in alcohol use disorder and alcohol-associated liver disease: A narrative review.
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DOI：
10.1111/acer.14967
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发表时间：
2022-12
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影响因子：
--
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中科院分区：
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--
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不健康的酒精消费是一个全球性的健康问题。个人和公共健康以及社会经济后果可归因于有害的酒精使用。流行病学研究表明，酒精使用障碍（AUD）和酒精相关性肝病（ALD）是酒精相关疾病中排名前两位的病理。与肝脏在酒精代谢中发挥的主要作用相一致，不受控制的饮酒可能会对肝脏造成重大损害。这种损害是由肝脏中过量的脂肪积累引起的，这可能进一步发展为晚期肝病。目前对ALD唯一有效的治疗策略是戒酒或肝移植。任何在控制成瘾行为和相关代谢途径的中枢和外周器官中具有双重作用的分子都可能成为治疗AUD和ALD的有希望的治疗靶点。Ghrelin是一种主要来源于胃的激素，具有这种特性并调节行为和代谢功能。在这篇综述中，我们强调了最近的进展，了解外周和中枢功能的生长激素释放肽系统及其在AUD和ALD发病机制中的作用。我们首先讨论血中生长激素释放肽浓度与饮酒或戒酒之间的相关性。接下来，我们讨论了ghrelin在酒精寻求行为中的作用，最后通过代谢调节和器官串扰讨论了ghrelin在脂肪肝发展中的作用。我们认为，了解ghrelin系统可能会为改善AUD和相关医疗后果（包括ALD）的治疗开辟一条创新途径。
Unhealthy alcohol consumption is a global health problem. Individual and public health, and socioeconomic consequences are attributable to harmful alcohol use. Epidemiological studies have shown that alcohol use disorder (AUD) and alcohol-associated liver disease (ALD) are the top two pathologies among alcohol-related diseases. Consistent with the major role that the liver plays in alcohol metabolism, uncontrolled drinking may cause significant damage to the liver. This damage is initiated with excessive fat accumulation in the liver, which can further progress to advanced liver disease. The only effective therapeutic strategies currently available for ALD are alcohol abstinence or liver transplantation. Any molecule with dual pronged effects at the central and peripheral organs controlling addictive behaviors and associated metabolic pathways could be a promising therapeutic target to treat AUD and ALD. Ghrelin, a hormone primarily derived from the stomach, has such properties and regulates both behavioral and metabolic functions. In this review, we highlight recent advances in understanding the peripheral and central functions of the ghrelin system and its role in AUD and ALD pathogenesis. We first discuss the correlation between blood ghrelin concentrations and alcohol use or abstinence. Next, we discuss the role of ghrelin in alcohol-seeking behaviors, and finally its role in development of fatty liver by metabolic regulations and organ-crosstalk. We propose that understanding the ghrelin system may open an innovative avenue for improved treatments for AUD and associated medical consequences, including ALD.
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影响因子：
9.8
作者：
Calissendorff, Jan;Danielsson, Olle;Rojdmark, Sven
通讯作者：
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