New Peptides as Potential Players in the Crosstalk Between the Brain and Obesity, Metabolic and Cardiovascular Diseases.
New Peptides as Potential Players in the Crosstalk Between the Brain and Obesity, Metabolic and Cardiovascular Diseases.
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DOI：
10.3389/fphys.2021.692642
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发表时间：
2021
影响因子：
4
通讯作者：
Cudnoch-Jędrzejewska A
中科院分区：
文献类型：
--
作者：
Czerwińska M;Czarzasta K;Cudnoch-Jędrzejewska A
根据世界卫生组织2016年发布的报告，全球有6.5亿人患有肥胖症，几乎是1975年的三倍。肥胖症是指脂肪堆积过多，可能会损害健康的非传染性疾病，如糖尿病，心血管疾病（高血压，冠状动脉疾病，中风），和一些癌症。尽管医学进步，心血管并发症仍然是肥胖引起的死亡的主要原因。脂肪的过度积累是由于能量的摄入和消耗不平衡造成的。这一过程的发病机制是复杂的，尚未完全理解，但目前的研究集中在中枢神经系统（CNS），神经内分泌和免疫系统，包括自主神经系统，脂肪组织，消化和心血管系统之间的复杂串扰的作用。此外，特别关注新发现的物质：神经肽26RFa，preptin和adropin。已表明，上述肽在CNS的许多结构和许多外周器官和组织如心脏、脂肪组织和胃肠道中合成。近年来，这些肽在肥胖、代谢和心血管系统疾病的发病机制中的作用受到了特别的关注。本文综述了新研究的肽在肥胖、代谢和心血管疾病发病机制中脑和外周器官之间的串扰中的作用。
According to the World Health Organization report published in 2016, 650 million people worldwide suffer from obesity, almost three times more than in 1975. Obesity is defined as excessive fat accumulation which may impair health with non-communicable diseases such as diabetes, cardiovascular diseases (hypertension, coronary artery disease, stroke), and some cancers. Despite medical advances, cardiovascular complications are still the leading causes of death arising from obesity. Excessive fat accumulation is caused by the imbalance between energy intake and expenditure. The pathogenesis of this process is complex and not fully understood, but current research is focused on the role of the complex crosstalk between the central nervous system (CNS), neuroendocrine and immune system including the autonomic nervous system, adipose tissue, digestive and cardiovascular systems. Additionally, special attention has been paid to newly discovered substances: neuropeptide 26RFa, preptin, and adropin. It was shown that the above peptides are synthesized both in numerous structures of the CNS and in many peripheral organs and tissues, such as the heart, adipose tissue, and the gastrointestinal tract. Recently, particular attention has been paid to the role of the presented peptides in the pathogenesis of obesity, metabolic and cardiovascular system diseases. This review summarizes the role of newly investigated peptides in the crosstalk between brain and peripheral organs in the pathogenesis of obesity, metabolic, and cardiovascular diseases.
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DOI：
10.4149/bll_2016_020
发表时间：
2016-01-01
影响因子：
1.5
作者：
Akcilar, R.;Kocak, F. E.;Kokdasgil, H.
通讯作者：
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影响因子：
3
作者：
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影响因子：
4.7
作者：
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影响因子：
9.8
作者：
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通讯作者：
Lopaschuk, Gary D.
影响因子：
1.4
作者：
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通讯作者：
Sayin, Oya