Thermo-/pH-dual responsive properties of hyperbranched polyethylenimine grafted by phenylalanine.
Thermo-/pH-dual responsive properties of hyperbranched polyethylenimine grafted by phenylalanine.
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苯丙氨酸接枝超支化聚乙烯亚胺的热/pH双重响应特性
DOI：
10.1007/s12272-013-0288-y
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发表时间：
2014-01
影响因子：
6.7
通讯作者：
Chen, Xuesi
中科院分区：
文献类型：
--
作者：
Chen, Jie;Xia, Jialiang;Tian, Huayu;Tang, Zhaohui;He, Chaoliang;Chen, Xuesi
以超支化聚乙烯亚胺（PEI）为原料，通过接枝L-苯丙氨酸，合成了具有温度和pH双重响应性的两亲性共聚物。苯丙氨酸修饰的PEI表现出比商业PEI更低的细胞毒性。这些共聚物显示响应于pH和温度的相变现象。低pH值的共聚物稀溶液具有较高的LCST。LCST随苯丙氨酸接枝密度的增加而增加。这些共聚物的LCST通过酰胺化程度和溶液的pH在7.2至59.6 °C之间可调。DLS和TEM实验证明，当温度高于LCST时，共聚物链发生聚集，形成小尺寸粒子。因此，所获得的智能共聚物被认为是生物医学领域中潜在的基因/药物载体。
Novel thermo- and pH-dual responsive amphiphilic copolymers were synthesized based on hyperbranched polyethylenimine (PEI) by graftingl-phenylalanine. The phenylalanine-modified PEI exhibited lower cytotoxicity than commercial PEI. These copolymers showed the phenomena of phase transitions in response to pH and temperature. The dilute copolymer solution at lower pH displayed the higher LCST. Furthermore, LCST increased with the increasing of phenylalanine grafting density. LCST of these copolymers were tunable from 7.2 to 59.6 °C by the degree of amidation and pH of solution. DLS and TEM experiments certified that the copolymer chains aggregated to form small size particles as increasing the temperature above LCST. For these reasons, the obtained smart copolymers were considered to be potential gene/drug carriers in biomedical field.
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