Rapid cell population identification in flow cytometry data.
Rapid cell population identification in flow cytometry data.
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DOI:
10.1002/cyto.a.21007
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发表时间:
2011-01
期刊:
影响因子:
3.7
通讯作者:
Brinkman, Ryan R.
中科院分区:
文献类型:
--
作者:
Aghaeepour, Nima;Nikolic, Radina;Hoos, Holger H.;Brinkman, Ryan R.
We have developed flowMeans, a time-efficient and accurate method for automated identification of cell populations in flow cytometry (FCM) data based on K-means clustering. Unlike traditional K-means, flowMeans can identify concave cell populations by modelling a single population with multiple clusters. flowMeans uses a change point detection algorithm to determine the number of sub-populations, enabling the method to be used in high throughput FCM data analysis pipelines. Our approach compares favourably to manual analysis by human experts and current state-of-the-art automated gating algorithms. flowMeans is freely available as an open source R package through Bioconductor.
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影响因子:
--
作者:
Finak G;Bashashati A;Brinkman R;Gottardo R
通讯作者:
Gottardo R
影响因子:
12.3
作者:
Gentleman RC;Carey VJ;Bates DM;Bolstad B;Dettling M;Dudoit S;Ellis B;Gautier L;Ge Y;Gentry J;Hornik K;Hothorn T;Huber W;Iacus S;Irizarry R;Leisch F;Li C;Maechler M;Rossini AJ;Sawitzki G;Smith C;Smyth G;Tierney L;Yang JY;Zhang J
通讯作者:
Zhang J
DOI:
10.1002/cyto.10084
发表时间:
2002-04-15
期刊:
CYTOMETRY
影响因子:
--
作者:
Gratama, JW;Kraan, J;Barnett, D
通讯作者:
Barnett, D
影响因子:
3.7
作者:
Lo, Kenneth;Brinkman, Ryan Remy;Gottardo, Raphael
通讯作者:
Gottardo, Raphael
影响因子:
3.7
作者:
Naumann, U.;Wand, M. P.
通讯作者:
Wand, M. P.