Functions of exosomal non-coding RNAs to the infection with Mycobacterium tuberculosis.

Functions of exosomal non-coding RNAs to the infection with Mycobacterium tuberculosis.
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DOI:
10.3389/fimmu.2023.1127214
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发表时间:
2023
影响因子:
7.3
通讯作者:
Tang, Lijun
Tang, Lijun
中科院分区:
医学2区
文献类型:
--
作者:
Wang, Jianjun;Li, Yujie;Wang, Nan;Wu, Jianhong;Ye, Xiaojian;Jiang, Yibiao;Tang, Lijun

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结核病(TB)是由结核分枝杆菌(M. TB)引起的一种主要传染病,是世界上主要的致命性细菌传染病。越来越多的研究表明,外泌体可能是诊断和治疗结核病的新选择。外泌体是一种纳米囊泡(30- 150nm),含有各种细胞释放的脂质、蛋白质和非编码rna (ncRNAs),可以在细胞间转运和交流。此外,外泌体ncRNAs在包括结核病在内的细菌感染中表现出诊断潜力。此外,差异外泌体ncRNAs调节结核分枝杆菌感染细胞的生理和病理功能,并作为结核的诊断标志物。本文综述了外泌体ncrna的潜在生物学作用和诊断应用前景,并介绍了其在结核病中的致病和治疗功能的最新信息。
Tuberculosis (TB) is a major infectious disease induced by Mycobacterium tuberculosis (M. tb) which causes the world’s dominant fatal bacterial contagious disease. Increasing studies have indicated that exosomes may be a novel option for the diagnosis and treatment of TB. Exosomes are nanovesicles (30-150 nm) containing lipids, proteins and non-coding RNAs (ncRNAs) released from various cells, and can transfer their cargos and communicate between cells. Furthermore, exosomal ncRNAs exhibit diagnosis potential in bacterial infections, including TB. Additionally, differential exosomal ncRNAs regulate the physiological and pathological functions of M. tb-infected cells and act as diagnostic markers for TB. This current review explored the potential biological roles and the diagnostic application prospects of exosomal ncRNAs, and included recent information on their pathogenic and therapeutic functions in TB.
DOI: 10.3389/fimmu.2022.878471
发表时间: 2022
影响因子: 7.3
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