Extracellular haem utilization by the opportunistic pathogen Pseudomonas aeruginosa and its role in virulence and pathogenesis.
Extracellular haem utilization by the opportunistic pathogen Pseudomonas aeruginosa and its role in virulence and pathogenesis.
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DOI：
10.1016/bs.ampbs.2021.07.004
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发表时间：
2021
影响因子：
--
通讯作者：
Wilks A
中科院分区：
文献类型：
--
作者：
Mouriño S;Wilks A
铁是所有细菌必需的微量营养素，但由于其有限的生物利用度，提出了一个重大挑战。此外，铁的毒性以及维持铁水平在狭窄生理范围内的需要需要综合系统来感知、调节和运输各种铁复合物。大多数细菌编码系统通过铁载体受体介导的摄取或通过细胞质能量依赖的运输系统螯合和运输铁（Fe3+）。致病菌通过利用血红素作为铁的来源，进一步降低了获取铁的屏障。血红素是一种亲脂和有毒的分子，对运输到细胞中提出了重大挑战。因此，致病菌已经进化出复杂的细胞表面信号（CSS）和运输系统来感知和获取宿主的血红素。一旦内化血红素被氧化和非氧化机制劈裂释放铁。在此，我们总结了目前对铜绿假单胞菌血红素感知、摄取和利用的机制，其在发病机制和毒力中的作用，以及这些系统作为抗菌靶点的潜力的理解。
Iron is an essential micronutrient for all bacteria but presents a significant challenge given its limited bioavailability. Furthermore, iron’s toxicity combined with the need to maintain iron levels within a narrow physiological range requires integrated systems to sense, regulate and transport a variety of iron complexes. Most bacteria encode systems to chelate and transport ferric iron (Fe3+) via siderophore receptor mediated uptake or via cytoplasmic energy dependent transport systems. Pathogenic bacteria have further lowered the barrier to iron acquisition by employing systems to utilize haem as a source of iron. Haem, a lipophilic and toxic molecule, presents a significant challenge for transport into the cell. As such pathogenic bacteria have evolved sophisticated cell surface signaling (CSS) and transport systems to sense and obtain haem from the host. Once internalized haem is cleaved by both oxidative and non-oxidative mechanisms to release iron. Herein we summarize our current understanding of the mechanism of haem sensing, uptake and utilization in Pseudomonas aeruginosa, its role in pathogenesis and virulence, and the potential of these systems as antimicrobial targets.
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DOI：
10.1016/j.ijantimicag.2004.06.008
发表时间：
2004-12-01
影响因子：
10.8
作者：
Bozja, J;Yi, K;Stojilikovic, I
通讯作者：
Stojilikovic, I
影响因子：
14.9
作者：
Casas-Pastor D;Müller RR;Jaenicke S;Brinkrolf K;Becker A;Buttner MJ;Gross CA;Mascher T;Goesmann A;Fritz G
通讯作者：
Fritz G
影响因子：
3.5
作者：
Clifton, Matthew C.;Corrent, Colin;Strong, Roland K.
通讯作者：
Strong, Roland K.
影响因子：
3.6
作者：
Chen, CC;Lewis, RJ;Delumeau, O
通讯作者：
Delumeau, O
影响因子：
11.3
作者：
Becker KW;Skaar EP
通讯作者：
Skaar EP