Taurine and inflammatory diseases.
Taurine and inflammatory diseases.
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DOI：
10.1007/s00726-012-1361-4
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发表时间：
2014-01
期刊：
影响因子：
3.5
通讯作者：
Kontny E
中科院分区：
文献类型：
--
作者：
Marcinkiewicz J;Kontny E
牛磺酸（2-氨基乙磺酸）是人体中含量最丰富的游离氨基酸，在胆汁酸偶联、钙稳态维持、渗透调节和膜稳定等重要生物过程中起着重要作用。此外，细胞凋亡的衰减及其抗氧化活性似乎对牛磺酸的细胞保护作用至关重要。虽然这些特性不是组织特异性的，但牛磺酸在暴露于高水平氧化剂（如炎症细胞）的组织中达到特别高的浓度。这表明牛磺酸可能在与氧化应激相关的炎症中发挥重要作用。事实上，在炎症部位，已知牛磺酸与中性粒细胞髓过氧化物酶(MPO) -卤化物系统产生的次氯酸反应并解毒。这个反应产生毒性较小的牛磺酸氯胺（TauCl）。牛磺酸与次溴酸（HOBr）反应的产物牛磺酸溴胺（TauBr）和牛磺酸溴胺（TauCl）都具有抗菌和抗炎作用。与牛磺酸和牛磺酸卤胺（TauCl, taaubr）在急性炎症中的调节作用相比，它们在炎症性疾病发病机制中的作用尚不清楚。本文综述了目前关于牛磺酸、TauCl和TauBr在mpo衍生氧化剂引发或传播的炎症性疾病发病机制中的作用。本文的目的是展示炎症、中性粒细胞、MPO、氧化应激和牛磺酸之间的联系。我们将讨论牛磺酸和牛磺酸卤胺对炎症性疾病发病机制的可能贡献，特别是在类风湿关节炎的最佳研究实例中。
Taurine (2-aminoethanesulfonic acid) is the most abundant free amino acid in humans and plays an important role in several essential biological processes such as bile acid conjugation, maintenance of calcium homeostasis, osmoregulation and membrane stabilization. Moreover, attenuation of apoptosis and its antioxidant activity seem to be crucial for the cytoprotective effects of taurine. Although these properties are not tissue specific, taurine reaches particularly high concentrations in tissues exposed to elevated levels of oxidants (e.g., inflammatory cells). It suggests that taurine may play an important role in inflammation associated with oxidative stress. Indeed, at the site of inflammation, taurine is known to react with and detoxify hypochlorous acid generated by the neutrophil myeloperoxidase (MPO)–halide system. This reaction results in the formation of less toxic taurine chloramine (TauCl). Both haloamines, TauCl and taurine bromamine (TauBr), the product of taurine reaction with hypobromous acid (HOBr), exert antimicrobial and anti-inflammatory properties. In contrast to a well-documented regulatory role of taurine and taurine haloamines (TauCl, TauBr) in acute inflammation, their role in the pathogenesis of inflammatory diseases is not clear. This review summarizes our current knowledge concerning the role of taurine, TauCl and TauBr in the pathogenesis of inflammatory diseases initiated or propagated by MPO-derived oxidants. The aim of this paper is to show links between inflammation, neutrophils, MPO, oxidative stress and taurine. We will discuss the possible contribution of taurine and taurine haloamines to the pathogenesis of inflammatory diseases, especially in the best studied example of rheumatoid arthritis.
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影响因子：
4.4
作者：
Barua, M;Liu, Y;Quinn, MR
通讯作者：
Quinn, MR
DOI：
10.1016/0162-3109(96)00113-0
发表时间：
1996-09-01
期刊：
IMMUNOPHARMACOLOGY
影响因子：
--
作者：
Kim, C;Park, E;SchullerLevis, G
通讯作者：
SchullerLevis, G
影响因子：
5.6
作者：
Kim, Chaekyun;Jang, Jin Sun;Cha, Young-Nam
通讯作者：
Cha, Young-Nam
牛磺酸氯胺差异抑制了白介素-1beta中的基质金属蛋白酶1和13合成刺激的成纤维细胞样细胞。
影响因子：
4.9
作者：
Kim, Kyoung Soo;Park, Eun Kyung;Ju, Seung Min;Jung, Hye-Sook;Bang, Jun Soo;Kim, Chaekyun;Lee, Yeon-Ah;Hong, Seung-Jae;Lee, Sang-Hoon;Yang, Hyung-In;Yoo, Myung Chul
通讯作者：
Yoo, Myung Chul
DOI：
10.1097/01.mco.0000247469.26414.55
发表时间：
2006-11-01
影响因子：
3.1
作者：
Bouckenooghe, Thomas;Remacle, Claude;Reusens, Brigitte
通讯作者：
Reusens, Brigitte