Using techno-economic modelling to determine the minimum cost possible for a microbial palm oil substitute.
Using techno-economic modelling to determine the minimum cost possible for a microbial palm oil substitute.
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DOI：
10.1186/s13068-021-01911-3
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发表时间：
2021-03-04
影响因子：
6.3
通讯作者：
Chuck CJ
中科院分区：
文献类型：
--
作者：
Karamerou EE;Parsons S;McManus MC;Chuck CJ
异养单细胞油（SCOs）是棕榈油等第一代作物中提取的脂质生物燃料的潜在替代品。然而，尽管在这一领域进行了大量的实验研究，但只有少数技术经济模型出版物。因此，对于sco是否是，或者是否可能成为潜在的竞争性替代品，人们知之甚少。为了帮助解决这个问题，我们设计了一个详细的模型，将一个假设的异养型（使用最好的生物脂质生产）与最大、最有效的化工厂设计相结合。我们的基本情况是，对于年产量约8000吨的脂质销售价格为1.81美元/公斤，如果将产量增加到每年约48000吨的脂质，价格可能降至1.20美元/公斤。然后评估了进一步降低成本的一系列方案，包括使用耐热菌株（将成本从1.20美元降低到1.15美元/公斤），零成本电力（1.12美元/公斤），使用非无菌条件（1.19美元/公斤），湿法提取脂质（1.16美元/公斤），连续生产细胞外脂质（0.99美元/公斤）和销售整个酵母细胞，包括蛋白质和碳水化合物的回收价值（0.81美元/公斤）。如果与脂质一起生产副产物，那么价格可以有效地降低到0美元，这取决于从脂质生产中流出的碳量，只要副产物的售价超过1美元/公斤。这里提出的模型代表了一种理想的情况，尽管在现实中无法实现，但重要的是，无论该领域的科学进步如何，它都无法得到改善。从所探索的场景来看，生产成本较低的sco是可能的，但研究必须开始在三个关键领域应用，首先设计使用整个电池的产品。其次，进一步研究在细胞外连续加工方法中产生脂质的产品系统，或者最终创建一个有效的生物精炼厂，设计用于生产低分子量的散装化学品，以及脂质。所有其他的研究领域只会带来渐进式的收益，而不会带来经济上有竞争力的、可持续的微生物油。
Heterotrophic single-cell oils (SCOs) are one potential replacement to lipid-derived biofuels sourced from first-generation crops such as palm oil. However, despite a large experimental research effort in this area, there are only a handful of techno-economic modelling publications. As such, there is little understanding of whether SCOs are, or could ever be, a potential competitive replacement. To help address this question, we designed a detailed model that coupled a hypothetical heterotroph (using the very best possible biological lipid production) with the largest and most efficient chemical plant design possible. Our base case gave a lipid selling price of $1.81/kg for ~ 8,000 tonnes/year production, that could be reduced to $1.20/kg on increasing production to ~ 48,000 tonnes of lipid a year. A range of scenarios to further reduce this cost were then assessed, including using a thermotolerant strain (reducing the cost from $1.20 to $1.15/kg), zero-cost electricity ($ 1.12/kg), using non-sterile conditions ($1.19/kg), wet extraction of lipids ($1.16/kg), continuous production of extracellular lipid ($0.99/kg) and selling the whole yeast cell, including recovering value for the protein and carbohydrate ($0.81/kg). If co-products were produced alongside the lipid then the price could be effectively reduced to $0, depending on the amount of carbon funnelled away from lipid production, as long as the co-product could be sold in excess of $1/kg. The model presented here represents an ideal case that which while not achievable in reality, importantly would not be able to be improved on, irrespective of the scientific advances in this area. From the scenarios explored, it is possible to produce lower cost SCOs, but research must start to be applied in three key areas, firstly designing products where the whole cell is used. Secondly, further work on the product systems that produce lipids extracellularly in a continuous processing methodology or finally that create an effective biorefinery designed to produce a low molecular weight, bulk chemical, alongside the lipid. All other research areas will only ever give incremental gains rather than leading towards an economically competitive, sustainable, microbial oil.
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影响因子：
3.3
作者：
Braunwald, Teresa;French, William Todd;Graeff-Hoenninger, Simone
通讯作者：
Graeff-Hoenninger, Simone
影响因子：
3.9
作者：
Cui, Yi;Liang, Yanna
通讯作者：
Liang, Yanna
DOI：
10.1002/jctb.5597
发表时间：
2018-08
期刊：
Journal of chemical technology and biotechnology (Oxford, Oxfordshire : 1986)
影响因子：
--
作者：
Chantasuban T;Santomauro F;Gore-Lloyd D;Parsons S;Henk D;Scott RJ;Chuck C
通讯作者：
Chuck C
影响因子：
5.1
作者：
Cajka, Tomas;Garay, Luis A.;Fiehn, Oliver
通讯作者：
Fiehn, Oliver
影响因子：
7.4
作者：
Bonatsos, Nikolaos;Marazioti, Constantina;Kookos, Ioannis K.
通讯作者：
Kookos, Ioannis K.