Multiplexed action-outcome representation by striatal striosome-matrix compartments detected with a mouse cost-benefit foraging task.
Multiplexed action-outcome representation by striatal striosome-matrix compartments detected with a mouse cost-benefit foraging task.
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DOI：
10.1038/s41467-022-28983-5
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发表时间：
2022-03-22
影响因子：
16.6
通讯作者：
Graybiel AM
中科院分区：
文献类型：
--
作者：
Bloem B;Huda R;Amemori KI;Abate AS;Krishna G;Wilson AL;Carter CW;Sur M;Graybiel AM
了解行动的积极和消极结果对生存至关重要，并得到包括纹状体在内的保守回路的支持。行动和结果之间的联系是如何形成的还不完全清楚，特别是当结果混合了积极和消极的特征时。我们开发了一种新的觅食（“强盗”）任务，要求老鼠在最小化惩罚的同时最大化奖励。采用双光子ca++成像技术，对视觉识别的前嗅纹状体和基质神经元的活性进行了监测。我们发现奖励和惩罚的行为-结果关联在部分重叠的人群中是并行编码的。对于一个动作，单个神经元可以编码相反价的结果。纹状体区室始终表现出比矩阵更强的强化结果表征，特别是对于高奖惩预测误差。这些发现证明了单一纹状体神经元对动作-结果偶发的多重作用，并表明纹状体神经元在动作-结果学习中尤为重要。纹状体在跟踪行为之间的联系以及奖励和厌恶结果的组合方面所起的作用尚不清楚。在这里，通过在小鼠中使用钙成像和强化学习模型，作者发现单个纹状体神经元可以编码行为和多种（有时是相互冲突的）结果之间的关联。
Learning about positive and negative outcomes of actions is crucial for survival and underpinned by conserved circuits including the striatum. How associations between actions and outcomes are formed is not fully understood, particularly when the outcomes have mixed positive and negative features. We developed a novel foraging (‘bandit’) task requiring mice to maximize rewards while minimizing punishments. By 2-photon Ca++ imaging, we monitored activity of visually identified anterodorsal striatal striosomal and matrix neurons. We found that action-outcome associations for reward and punishment were encoded in parallel in partially overlapping populations. Single neurons could, for one action, encode outcomes of opposing valence. Striosome compartments consistently exhibited stronger representations of reinforcement outcomes than matrix, especially for high reward or punishment prediction errors. These findings demonstrate multiplexing of action-outcome contingencies by single identified striatal neurons and suggest that striosomal neurons are particularly important in action-outcome learning. The role that the striatum plays in tracking the association between actions and combinations of rewarding and aversive outcomes remains unclear. Here, by using both calcium imaging in mice and reinforcement learning models, the authors find that individual striatal neurons can encode associations between actions and multiple, sometimes conflicting, outcomes.
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基底神经节抑制输入对黑质多巴胺能神经元的功能剖析。
影响因子：
8.8
作者：
Evans, Rebekah C.;Twedell, Emily L.;Zhu, Manhua;Ascencio, Jefferson;Zhang, Renshu;Khaliq, Zayd M.
通讯作者：
Khaliq, Zayd M.
神经元型特异性信号，用于腹侧对段区域的奖励和惩罚。
影响因子：
64.8
作者：
Cohen, Jeremiah Y.;Haesler, Sebastian;Vong, Linh;Lowell, Bradford B.;Uchida, Naoshige
通讯作者：
Uchida, Naoshige
影响因子：
16.2
作者：
Banghart MR;Neufeld SQ;Wong NC;Sabatini BL
通讯作者：
Sabatini BL
DOI：
10.1073/pnas.1613337113
发表时间：
2016-10-04
影响因子：
11.1
作者：
Crittenden, Jill R.;Tillberg, Paul W.;Graybiel, Ann M.
通讯作者：
Graybiel, Ann M.
DOI：
10.1080/14640748108400816
发表时间：
1981-01-01
期刊：
QUARTERLY JOURNAL OF EXPERIMENTAL PSYCHOLOGY SECTION B-COMPARATIVE AND PHYSIOLOGICAL PSYCHOLOGY
影响因子：
--
作者：
ADAMS, CD;DICKINSON, A
通讯作者：
DICKINSON, A