Emotional face processing in pediatric bipolar disorder: evidence for functional impairments in the fusiform gyrus.
Emotional face processing in pediatric bipolar disorder: evidence for functional impairments in the fusiform gyrus.
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DOI：
10.1016/j.jaac.2013.09.004
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发表时间：
2013-12
影响因子：
13.3
通讯作者：
Phillips, Mary L.
中科院分区：
文献类型：
--
作者：
Perlman, Susan B.;Fournier, Jay C.;Bebko, Genna;Bertocci, Michele A.;Hinze, Amanda K.;Bonar, Lisa;Almeida, Jorge R. C.;Versace, Amelia;Schirda, Claudiu;Travis, Michael;Gill, Mary Kay;Demeter, Christine;Diwadkar, Vaibhav A.;Sunshine, Jeffrey L.;Holland, Scott K.;Kowatch, Robert A.;Birmaher, Boris;Axelson, David;Horwitz, Sarah M.;Arnold, L. Eugene;Fristad, Mary A.;Youngstrom, Eric A.;Findling, Robert L.;Phillips, Mary L.
关键词：
儿科双相情感障碍涉及社交功能低下，但这些缺陷背后的神经机制尚不清楚。先前的神经影像学研究发现，情绪化的面部处理局限于大脑的情绪区域。然而，很少有研究检查面部处理电路其他区域的功能障碍。本研究评估了儿童双相情感障碍患者大脑中关键面孔处理区域的激活不足。将双相情感障碍患者（n=20）与非双相情感障碍临床组（n=20）和健康对照组（n = 20）相匹配，非双相情感障碍临床组具有相似的人口统计学特征和共病诊断。青少年参与了功能性磁共振成像（fMRI）扫描，采用了任务无关的情绪处理设计，其中面部情绪的处理与任务表现无关。与匹配的临床和健康对照组相比，当观察儿童双相情感障碍参与者的快乐、悲伤、恐惧，特别是愤怒的动画、新兴面部表情时，发现了孤立于梭状回的低激活。这项研究的结果意味着，大脑面部处理系统的视觉区域存在差异，而不仅仅是孤立于情感大脑区域，如杏仁核。研究结果进行了讨论，在有关面部情绪识别和梭状回赤字先前报道的自闭症文献。针对面部刺激的行为干预可能被探索为青年双相情感障碍的可能治疗方法。
Pediatric bipolar disorder involves poor social functioning, but the neural mechanisms underlying these deficits are not well understood. Previous neuroimaging studies have found deficits in emotional face processing localized to emotional brain regions. However, few studies have examined dysfunction in other regions of the face processing circuit. This study assessed hypoactivation in key face processing regions of the brain in pediatric bipolar disorder. Youth with a bipolar spectrum diagnosis (n=20) were matched to a nonbipolar clinical group (n=20), with similar demographics and comorbid diagnoses, and a healthy control group (n=20). Youth participated in a functional magnetic resonance imaging (fMRI) scanning which employed a task-irrelevant emotion processing design in which processing of facial emotions was not germane to task performance. Hypoactivation, isolated to the fusiform gyrus, was found when viewing animated, emerging facial expressions of happiness, sadness, fearfulness, and especially anger in pediatric bipolar participants relative to matched clinical and healthy control groups. The results of the study imply that differences exist in visual regions of the brain’s face processing system and are not solely isolated to emotional brain regions, such as the amygdala. Findings are discussed in relation to facial emotion recognition and fusiform gyrus deficits previously reported in the autism literature. Behavioral interventions targeting attention to facial stimuli might be explored as possible treatments for bipolar disorder in youth.
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DOI：
10.1097/chi.0b013e318188832e
发表时间：
2008-12
影响因子：
13.3
作者：
Brotman MA;Skup M;Rich BA;Blair KS;Pine DS;Blair JR;Leibenluft E
通讯作者：
Leibenluft E
影响因子：
17.7
作者：
Geller, B;Craney, JL;Zimerman, B
通讯作者：
Zimerman, B
DOI：
10.1176/appi.ajp.2009.09010043
发表时间：
2010-01
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Brotman MA;Rich BA;Guyer AE;Lunsford JR;Horsey SE;Reising MM;Thomas LA;Fromm SJ;Towbin K;Pine DS;Leibenluft E
通讯作者：
Leibenluft E
影响因子：
11.3
作者：
Adleman NE;Kayser RR;Olsavsky AK;Bones BL;Muhrer EJ;Fromm SJ;Pine DS;Zarate C;Leibenluft E;Brotman MA
通讯作者：
Brotman MA
DOI：
10.1016/s0926-6410(01)00054-4
发表时间：
2001-10-01
期刊：
COGNITIVE BRAIN RESEARCH
影响因子：
--
作者：
Campbell, R;MacSweeney, M;David, AS
通讯作者：
David, AS