Amygdala activation during emotion processing of neutral faces in children with severe mood dysregulation versus ADHD or bipolar disorder.
Amygdala activation during emotion processing of neutral faces in children with severe mood dysregulation versus ADHD or bipolar disorder.
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DOI：
10.1176/appi.ajp.2009.09010043
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发表时间：
2010-01
期刊：
影响因子：
--
通讯作者：
Leibenluft E
中科院分区：
文献类型：
--
作者：
Brotman MA;Rich BA;Guyer AE;Lunsford JR;Horsey SE;Reising MM;Thomas LA;Fromm SJ;Towbin K;Pine DS;Leibenluft E
为了了解疾病的独特和共同的病理生理学，需要在多个患者组中进行重叠症状的研究。情感处理缺陷和过度觉醒症状是双相情感障碍、注意缺陷多动障碍（ADHD）和严重情绪调节障碍的显著特征。作者比较了患有这些疾病的青少年以及一组健康对照青少年在对中性面孔进行情感和非情感评级时的杏仁核反应。在患有双相情感障碍（N=43）、ADHD（N=18）和严重情绪失调（N=29）的儿童和健康对照受试者（N=37）中检查杏仁核中的血氧水平依赖（BOLD）信号。在功能性磁共振成像（fMRI）中，参与者关注中性面孔的情感和非情感方面。在评定对中性面孔的主观恐惧时，ADHD青少年相对于其他三组表现出左杏仁核过度活跃，而严重情绪失调的青少年表现出活动减退。这些发现支持了独特的神经相关在双相情感障碍，多动症和严重情绪失调的青少年中的面部情绪处理中的作用。
To understand disorder-unique and common pathophysiology, studies in multiple patient groups with overlapping symptoms are needed. Deficits in emotion processing and hyperarousal symptoms are prominent features of bipolar disorder, attention deficit hyperactivity disorder (ADHD), and severe mood dysregulation. The authors compared amygdala response during emotional and nonemotional ratings of neutral faces in youths with these disorders as well as a group of healthy comparison youths. Blood-oxygen-level-dependent (BOLD) signal in the amygdala was examined in children with bipolar disorder (N=43), ADHD (N=18), and severe mood dysregulation (N=29) and healthy comparison subjects (N=37). During functional magnetic resonance imaging (fMRI), participants attended to emotional and nonemotional aspects of neutral faces. While rating subjective fear of neutral faces, youths with ADHD demonstrated left amygdala hyperactivity relative to the other three groups, whereas youths with severe mood dysregulation demonstrated hypoactivity. These findings support the role of unique neural correlates in face-emotion processing among youths with bipolar disorder, ADHD, and severe mood dysregulation.
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影响因子：
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作者：
Beesdo, Katja;Lau, Jennifer Y. F.;Guyer, Amanda E.;McClure-Tone, Erin B.;Monk, Christopher S.;Nelson, Eric E.;Fromm, Stephen J.;Goldwin, Michelle A.;Wittchen, Hans-Ulrich;Leibenluft, Ellen;Erns, Monique;Pine, Daniel S.
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