Assessing the Effects of Vitamin D on Neural Network Function in Patients With Parkinson's Disease by Measuring the Fraction Amplitude of Low-Frequency Fluctuation.
Assessing the Effects of Vitamin D on Neural Network Function in Patients With Parkinson's Disease by Measuring the Fraction Amplitude of Low-Frequency Fluctuation.
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DOI：
10.3389/fnagi.2021.763947
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发表时间：
2021
影响因子：
4.8
通讯作者：
Wang C
中科院分区：
文献类型：
--
作者：
Lv L;Zhang H;Tan X;Qin L;Peng X;Bai R;Xiao Q;Tan C;Liao H;Yan W;Tan J;Tang B;Wang C
背景资料：近年来，许多研究表明，低维生素D（VD）水平可能与帕金森病（PD）的风险增加有关，但其潜在机制尚不清楚。目的：探讨PD与VD水平的关系，分析VD对脑自发活动的影响，探讨其参与PD风险的可能机制。研究方法：在一项横断面研究中，我们量化了330名PD患者和209名健康对照（HC）之间VD水平的差异，以探讨VD与PD风险之间的相关性。我们还获得了46例PD患者和21例HC患者的静息态功能磁共振成像（rs-fMRI）数据。根据25（OH）D水平将PD患者分为VD缺乏组（PD + VDD）、VD不足组（PD + VDD）和VD正常组（PD + NVD）。通过测量低频波动幅度分数（fALFF）分析VD状态对全脑神经元自发活动的影响。结果：PD患者血清25（OH）D水平明显低于HC患者（23.60 ± 7.27vs.25.60 ± 5.78，P < 0.001）; 25（OH）D水平可能对PD风险具有潜在的剂量依赖性影响（P趋势= 0.007）。VD缺乏与PD高危相关[25（OH）D < 20 ng/mL，OR = 2.319]，25（OH）D浓度最低四分位数与PD高危相关（OR = 1.941）。在rs-fMRI研究中，与相应的HC组相比，PD + VDD患者的fALFF改变的脑区比其他PD组更宽。PD + VDD和PD + VDD均显示楔叶、左侧楔前叶、距状核皮质和右侧舌侧fALFF较高，左侧颞中回fALFF较低。PD + VDD患者在左侧额上级、额中、额下回以及左侧中央前回的fALFF也高于HC。在PD患者中，仅PD + VDD组和PD + NVD组之间的fALFF存在统计学显著差异。与PD + NVD组相比，PD + VDD组在左侧中央前回、左侧中央后回以及左侧顶下小叶的fALFF更高。结论：这些结果表明，PD患者的血清VD水平低于HC，VD可能对PD风险具有潜在的剂量依赖性影响。较低的血清VD水平可影响PD患者默认模式网络（DMN）和视觉通路神经元的自发神经元活动，为其影响PD风险提供了可能的机制。
Background: Recently, many studies have shown that low vitamin D (VD) levels may be related to an increased risk of Parkinson’s disease (PD), but the underlying mechanisms remain unclear. Objective: To explore the relationship between PD and VD levels, as well as to analyze the effects of VD on spontaneous brain activity and explore the possible mechanism of its involvement in PD risk. Methods: In a cross-sectional study, we quantified the difference in VD levels between 330 PD patients and 209 healthy controls (HC) to explore the correlation between VD and PD risk. We also acquired resting-state Functional Magnetic Resonance Imaging (rs-fMRI) data from 46 PD patients and 21 HC. The PD patients were divided into three groups according to 25(OH)D levels: PD patients with VD deficiency (PD + VDD), PD patients with VD insufficiency (PD + VDI), and PD patients with normal VD (PD + NVD). The effect of VD status on spontaneous neuronal activity in the whole brain was analyzed by measuring the fraction amplitude of low-frequency fluctuation (fALFF). Results: Compared with HC, the PD patients had lower serum 25(OH)D levels (23.60 ± 7.27 vs. 25.60 ± 5.78, P < 0.001). The 25(OH)D level may have a potential dose-dependent effect on the risk of PD (Ptrend = 0.007). A high risk of PD was associated with VD deficiency [25(OH)D < 20 ng/mL, OR = 2.319], and the lowest quartile of 25(OH)D concentration was associated with a high risk of PD (OR = 1.941). In the rs-fMRI study, PD + VDD patients had wider brain regions with altered fALFF than other PD groups when compared with the corresponding HC groups. Both PD + VDD and PD + VDI showed higher fALFF in the cuneus, left precuneus, calcarine cortex and right lingual, as well as lower fALFF in the left middle temporal gyrus. PD + VDD patients also showed higher fALFF in the left superior, middle and inferior frontal gyri, as well as the left precentral gyrus than HC. Among PD patients, there was only a statistically significant difference in fALFF between the PD + VDD and PD + NVD groups. Compared with the PD + NVD group, PD + VDD patients exhibited higher fALFF in the left precentral and left postcentral gyrus, as well as the left inferior parietal lobule. Conclusion: These results demonstrate that PD patients had lower serum VD levels than HC, and VD may have a potential dose-dependent effect on PD risk. Lower serum VD levels can affect the spontaneous neuronal activity of default-mode network (DMN) and visual pathway neurons in PD patients, providing a possible mechanism for its effect on PD risk.
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影响因子：
5.9
作者：
Jiang P;Zhang LH;Cai HL;Li HD;Liu YP;Tang MM;Dang RL;Zhu WY;Xue Y;He X
通讯作者：
He X
影响因子：
9.3
作者：
Lima LAR;Lopes MJP;Costa RO;Lima FAV;Neves KRT;Calou IBF;Andrade GM;Viana GSB
通讯作者：
Viana GSB
影响因子：
168.9
作者：
Kalia, Lorraine V.;Lang, Anthony E.
通讯作者：
Lang, Anthony E.
DOI：
10.1016/j.jsbmb.2016.04.006
发表时间：
2016-10-01
影响因子：
4.1
作者：
da Silva, Tatiana Claro;Hiller, Christian;Kullak-Ublick, Gerd A.
通讯作者：
Kullak-Ublick, Gerd A.
影响因子：
4.1
作者：
Cui, Xiaoying;Gooch, Helen;Eyles, Darryl
通讯作者：
Eyles, Darryl