Muscle moment arms and sensitivity analysis of a mouse hindlimb musculoskeletal model.
Muscle moment arms and sensitivity analysis of a mouse hindlimb musculoskeletal model.
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DOI：
10.1111/joa.12461
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发表时间：
2016-10
影响因子：
2.4
通讯作者：
Hutchinson JR
中科院分区：
文献类型：
--
作者：
Charles JP;Cappellari O;Spence AJ;Wells DJ;Hutchinson JR
肌肉骨骼建模已成为一种有价值的工具，用于了解神经，肌肉，骨骼和其他组织如何整合以产生运动。迄今为止，大多数肌肉骨骼建模工作都集中在人类或其近亲身上，很少有四足动物肢体模型的例子。小鼠后肢的肌肉骨骼模型可能对医学、遗传学、运动和神经科学中的问题具有广泛的实用性。这是由于该物种作为人类疾病的首要模型的地位，具有一系列用于在体内操纵动物的遗传工具，并且是一种小型四足动物，这是一种几乎没有模型存在的类别。在这里，描述了用于开发小鼠后肢和骨盆的第一个三维（3D）模型的方法。该模型代表了骨骼、关节和39个肌肉肌腱单元，是通过结合先前从显微解剖、对比增强微计算机断层扫描（CT）和数字分割中收集的肌肉结构数据创建的。该模型允许肌肉力矩臂，以及肌肉力量估计为每个musculotendon单位在整个范围内的关节旋转。力矩臂分析支持模型内肌肉肌腱单元放置的可靠性，并且与先前发表的大鼠后肢模型的比较进一步支持模型的可靠性。对模型的力产生参数和肌肉附着点进行的敏感性分析表明，最大等长肌肉力矩通常对肌腱松弛长度或插入坐标的变化最敏感，尽管力矩受影响的程度取决于几个因素。该模型代表了创建小鼠后肢和骨盆的全动态3D计算机模型的第一步，该模型适用于神经肌肉疾病，比较生物力学和运动的神经力学基础。捕捉肢体的形态和动力学，它使未来的神经和肌肉骨骼系统以及环境之间的复杂相互作用的解剖。
Musculoskeletal modelling has become a valuable tool with which to understand how neural, muscular, skeletal and other tissues are integrated to produce movement. Most musculoskeletal modelling work has to date focused on humans or their close relatives, with few examples of quadrupedal animal limb models. A musculoskeletal model of the mouse hindlimb could have broad utility for questions in medicine, genetics, locomotion and neuroscience. This is due to this species’ position as a premier model of human disease, having an array of genetic tools for manipulation of the animal in vivo, and being a small quadruped, a category for which few models exist. Here, the methods used to develop the first three‐dimensional (3D) model of a mouse hindlimb and pelvis are described. The model, which represents bones, joints and 39 musculotendon units, was created through a combination of previously gathered muscle architecture data from microdissections, contrast‐enhanced micro‐computed tomography (CT) scanning and digital segmentation. The model allowed muscle moment arms as well as muscle forces to be estimated for each musculotendon unit throughout a range of joint rotations. Moment arm analysis supported the reliability of musculotendon unit placement within the model, and comparison to a previously published rat hindlimb model further supported the model's reliability. A sensitivity analysis performed on both the force‐generating parameters and muscle's attachment points of the model indicated that the maximal isometric muscle moment is generally most sensitive to changes in either tendon slack length or the coordinates of insertion, although the degree to which the moment is affected depends on several factors. This model represents the first step in the creation of a fully dynamic 3D computer model of the mouse hindlimb and pelvis that has application to neuromuscular disease, comparative biomechanics and the neuromechanical basis of movement. Capturing the morphology and dynamics of the limb, it enables future dissection of the complex interactions between the nervous and musculoskeletal systems as well as the environment.
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影响因子：
3.7
作者：
Charles JP;Cappellari O;Spence AJ;Hutchinson JR;Wells DJ
通讯作者：
Wells DJ
影响因子：
3.2
作者：
Belić JJ;Faisal AA
通讯作者：
Faisal AA
影响因子：
5.1
作者：
Hasson CJ;Manczurowsky J
通讯作者：
Manczurowsky J
影响因子：
--
作者：
DeLaurier, April;Burton, Nicholas;Logan, Malcolm P. O.
通讯作者：
Logan, Malcolm P. O.
DOI：
10.1073/pnas.1419045111
发表时间：
2014-11-25
影响因子：
11.1
作者：
Akay, Turgay;Tourtellotte, Warren G.;Jessell, Thomas M.
通讯作者：
Jessell, Thomas M.