Patrilineal background of esophageal cancer and gastric cardia cancer patients in a Chaoshan high-risk area in China.
Patrilineal background of esophageal cancer and gastric cardia cancer patients in a Chaoshan high-risk area in China.
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我国潮汕高发区食管癌、胃癌患者的父系背景
DOI：
10.1371/journal.pone.0081670
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Su M
中科院分区：
文献类型：
--
作者：
Liu S;Huang B;Huang H;Li X;Chen G;Zhang G;Lin W;Guo D;Wang J;Yu Z;Liu X;Su M
我国中北部的太行山区、福建省南部地区和广东省潮汕平原是我国食管癌的三大高发区。这些地区也表现出贲门癌（GCC）的高发病率。潮汕人的祖先来自中国中北部，现在是潮汕平原的主要居民。我们假设潮汕地区的EC和GCC患者与太行山患者有共同的祖先。我们分析了16个东亚特有的Y染色体双等位基因标记（单核苷酸多态性; Y-SNPs）和6个Y染色体短串联重复序列（Y-STR）基因座72例EC和48例GCC患者来自潮汕和49例EC和63例GCC患者来自太行山区。我们还比较了32名潮汕客家人和24名居住在潮汕地区附近的畲族原住民的数据。采用Y-SNP的频率分布、主成分分析、相关分析和系统聚类分析进行分析。潮汕病人与太行山病人虽然地理上相距遥远，但关系密切。Y-STR分析显示，4个病例组之间的相关性较其他各组更密切。单倍群O3 a3 c1-M117的网络分析显示高度的患者特异性亚结构。我们认为这两个地区的EC和GCC患者具有相似的父系遗传背景，这可能在这些人群中EC和GCC的遗传因素中起重要作用。
The Taihang Mountain range of north-central China, the Southern region area of Fujian province, and the Chaoshan plain of Guangdong province are 3 major regions in China well known for their high incidence of esophageal cancer (EC). These areas also exhibit high incidences of gastric cardia cancer (GCC). The ancestors of the Chaoshanese, now the major inhabitants in the Chaoshan plain, were from north-central China. We hypothesized that EC and GCC patients in Chaoshan areas share a common ancestry with Taihang Mountain patients. We analyzed 16 East Asian-specific Y-chromosome biallelic markers (single nucleotide polymorphisms; Y-SNPs) and 6 Y-chromosome short tandem repeat (Y-STR) loci in 72 EC and 48 GCC patients from Chaoshan and 49 EC and 63 GCC patients from the Taihang Mountain range. We also compared data for 32 Chaoshan Hakka people and 24 members of the aboriginal She minority who live near the Chaoshan area. Analysis was by frequency distribution and principal component, correlation and hierarchical cluster analysis of Y-SNP. Chaoshan patients were closely related to Taihang Mountain patients, even though they are geographically distant. Y-STR analysis revealed that the 4 patient groups were more closely related with each other than with other groups. Network analysis of the haplogroup O3a3c1-M117 showed a high degree of patient-specific substructure. We suggest that EC and GCC patients from these 2 areas share a similar patrilineal genetic background, which may play an important role in the genetic factor of EC and GCC in these populations.
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DOI：
10.1007/bf02879329
发表时间：
2001-06-01
期刊：
SCIENCE IN CHINA SERIES C-LIFE SCIENCES
影响因子：
--
作者：
Ke, YH;Su, B;Lu, DR
通讯作者：
Lu, DR
三个中国食管癌高危人群的共同祖先的 Y 染色体证据。
影响因子：
3.7
作者：
Huang H;Su M;Li X;Li H;Tian D;Gao Y;Guo Y
通讯作者：
Guo Y
影响因子：
30.8
作者：
通讯作者：
--
影响因子：
2.8
作者：
Lin, Yinghua;Lai, Xiaolan;Huang, Huibin
通讯作者：
Huang, Huibin
影响因子：
9.8
作者：
Su, B;Xiao, JH;Jin, L
通讯作者：
Jin, L