Hippo Pathway Key to Ploidy Checkpoint

Hippo Pathway Key to Ploidy Checkpoint
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河马途径是倍性检查点的关键

DOI:
10.1016/j.cell.2014.07.041
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发表时间:
2014-08
期刊:
影响因子:
64.5
通讯作者:
Kun-Liang Guan
Kun-Liang Guan
中科院分区:
生物学1区
文献类型:
--
作者:
Bin Zhao;Kun-Liang Guan

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Tetraploid cells generated by abnormal cell division are often arrested during the cell cycle or cleared by apoptosis. Evasion of these defense mechanisms leads to genomic instability and tumorigenesis. In this issue, Ganem et al. report that extra centrosome-induced activation of the Hippo pathway kinase LATS2 is a key mechanism of tetraploidy-induced cell-cycle arrest.
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