Painted radioluminescence imaging with radioluminescent nanophosphors

Painted radioluminescence imaging with radioluminescent nanophosphors
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使用放射发光纳米磷光体绘制放射发光成像

DOI:
10.1063/5.0130428
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发表时间:
2022-12
影响因子:
4
通讯作者:
Cao Xu
Cao Xu
中科院分区:
物理与天体物理2区
文献类型:
--
作者:
Bai Tingting;Kang Fei;Zhu Shouping;Chen Xueli;Wang Yihan;Cao Xu

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像切伦科夫发光成像(CLI)或放射发光成像(RLI)这样的光学策略来成像临床可用的正电子发射断层扫描和单光子发射计算机断层扫描探针仍然存在低灵敏度和低分辨率的问题。本研究研究了一种彩色放射发光成像(PRLI)方法,该方法采用彩色闪烁体来提高临床使用18f -氟化脱氧核糖(18F-FDG)成像的信号和分辨率。幻影和体内实验结果表明,与基于柔性闪烁的RLI (Flexible radioluminescence imaging, FRLI)相比,PRLI可以实现比CLI高100倍的信号强度和更高的分辨率。PRLI使假肿瘤模型的信本比分别提高了81.8%(与CLI相比)和73.9%(与FRLI相比),肿瘤模型的信本比分别提高了60.0%(与CLI相比)和33.3%(与FRLI相比)。综上所述,PRLI是使用18F-FDG检测肿瘤的更有效的光学方法。
Optical strategies like Cerenkov luminescence imaging (CLI) or radioluminescence imaging (RLI) to image clinically available positron emission tomography and single photon emission computed tomography probes still suffer from low sensitivity or resolution. This study investigated a painted radioluminescence imaging (PRLI) approach that employed a painted scintillator to improve signal and resolution for imaging clinical used 18F-fluorinated deoxyribose (18F-FDG). Results of phantom and in vivo experiments revealed that PRLI could achieve ∼100 times higher signal intensity than CLI and higher resolution compared to Flexible radioluminescence imaging (FRLI), a flexible scintillation-based RLI. PRLI increased signal-to-background ratio in the pseudotumor model by 81.8% (compared to CLI) and 73.9% (compared to FRLI) as well as in the tumor model by 60.0% (compared to CLI) and 33.3% (compared to FRLI). As a conclusion, PRLI is a more effective optical approach for detecting tumors using 18F-FDG.
使用掺铽 Gd2O2S 微粒进行强度增强切伦科夫发光成像。
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期刊: ADVANCED MATERIALS
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