HIV-1 Remission: Accelerating the Path to Permanent HIV-1 Silencing.
HIV-1 Remission: Accelerating the Path to Permanent HIV-1 Silencing.
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DOI：
10.3390/v15112171
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发表时间：
2023-10-28
期刊：
影响因子：
--
通讯作者：
Ott M
中科院分区：
文献类型：
--
作者：
Lyons DE;Kumar P;Roan NR;Defechereux PA;Feschotte C;Lange UC;Murthy N;Sameshima P;Verdin E;Ake JA;Parsons MS;Nath A;Gianella S;Smith DM;Kallas EG;Villa TJ;Strange R;Mwesigwa B;Furler O'Brien RL;Nixon DF;Ndhlovu LC;Valente ST;Ott M
Despite remarkable progress, a cure for HIV-1 infection remains elusive. Rebound competent latent and transcriptionally active reservoir cells persevere despite antiretroviral therapy and rekindle infection due to inefficient proviral silencing. We propose a novel “block-lock-stop” approach, entailing long term durable silencing of viral expression towards an irreversible transcriptionally inactive latent provirus to achieve long term antiretroviral free control of the virus. A graded transformation of remnant HIV-1 in PLWH from persistent into silent to permanently defective proviruses is proposed, emulating and accelerating the natural path that human endogenous retroviruses (HERVs) take over millions of years. This hypothesis was based on research into delineating the mechanisms of HIV-1 latency, lessons from latency reversing agents and advances of Tat inhibitors, as well as expertise in the biology of HERVs. Insights from elite controllers and the availability of advanced genome engineering technologies for the direct excision of remnant virus set the stage for a rapid path to an HIV-1 cure.
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DOI：
10.1016/j.omtn.2018.05.021
发表时间：
2018-09-07
期刊：
Molecular therapy. Nucleic acids
影响因子：
--
作者：
Bella R;Kaminski R;Mancuso P;Young WB;Chen C;Sariyer R;Fischer T;Amini S;Ferrante P;Jacobson JM;Kashanchi F;Khalili K
通讯作者：
Khalili K
影响因子：
30.3
作者：
Baxter AE;Niessl J;Fromentin R;Richard J;Porichis F;Charlebois R;Massanella M;Brassard N;Alsahafi N;Delgado GG;Routy JP;Walker BD;Finzi A;Chomont N;Kaufmann DE
通讯作者：
Kaufmann DE
影响因子：
6.7
作者：
Hauber I;Hofmann-Sieber H;Chemnitz J;Dubrau D;Chusainow J;Stucka R;Hartjen P;Schambach A;Ziegler P;Hackmann K;Schröck E;Schumacher U;Lindner C;Grundhoff A;Baum C;Manz MG;Buchholz F;Hauber J
通讯作者：
Hauber J
影响因子：
3.7
作者：
Strong CL;Guerra HP;Mathew KR;Roy N;Simpson LR;Schiller MR
通讯作者：
Schiller MR
影响因子：
16.6
作者：
Dash, Prasanta K.;Kaminski, Rafal;Gendelman, Howard E.
通讯作者：
Gendelman, Howard E.