How the Chemical Properties of GBCAs Influence Their Safety Profiles In Vivo.
How the Chemical Properties of GBCAs Influence Their Safety Profiles In Vivo.
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DOI：
10.3390/molecules27010058
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发表时间：
2021-12-23
期刊：
影响因子：
--
通讯作者：
Kovacs Z
中科院分区：
文献类型：
--
作者：
Do QN;Lenkinski RE;Tircso G;Kovacs Z
细胞外类钆造影剂 (GBCA) 是临床诊断和疾病管理的重要工具。为了更好地了解与 GBCA 给药以及钆在人脑中保留和沉积相关的问题，我们将回顾 GBCA 的化学性质，例如相对热力学和动力学稳定性以及它们在体内形成钆沉积物的可能性。引起高信号的钆的化学形式是一个悬而未决的问题。根据对存在的总钆浓度的估计，完整螯合物不太可能引起人脑中观察到的 T1 高信号。尽管可能存在具有高弛豫率的水溶性形式的钆，但我们的经验表明，由于较高的水访问量，不溶性钆基试剂/盐在固体表面上可能具有高弛豫率。这篇综述根据 GBCA 的热力学和动力学特性，从化学角度评估了其安全性，讨论了这些特性如何影响体内行为，并强调了有关未来显像剂开发的一些临床意义。
The extracellular class of gadolinium-based contrast agents (GBCAs) is an essential tool for clinical diagnosis and disease management. In order to better understand the issues associated with GBCA administration and gadolinium retention and deposition in the human brain, the chemical properties of GBCAs such as relative thermodynamic and kinetic stabilities and their likelihood of forming gadolinium deposits in vivo will be reviewed. The chemical form of gadolinium causing the hyperintensity is an open question. On the basis of estimates of total gadolinium concentration present, it is highly unlikely that the intact chelate is causing the T1 hyperintensities observed in the human brain. Although it is possible that there is a water-soluble form of gadolinium that has high relaxitvity present, our experience indicates that the insoluble gadolinium-based agents/salts could have high relaxivities on the surface of the solid due to higher water access. This review assesses the safety of GBCAs from a chemical point of view based on their thermodynamic and kinetic properties, discusses how these properties influence in vivo behavior, and highlights some clinical implications regarding the development of future imaging agents.
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DOI：
10.3174/ajnr.a4378
发表时间：
2015-10
期刊：
AJNR. American journal of neuroradiology
影响因子：
--
作者：
Adin ME;Kleinberg L;Vaidya D;Zan E;Mirbagheri S;Yousem DM
通讯作者：
Yousem DM
影响因子：
2.8
作者：
BRUCHER, E;LAURENCZY, G;MAKRA, Z
通讯作者：
MAKRA, Z
影响因子：
4.7
作者：
Bussi, Simona;Coppo, Alessandra;Maisano, Federico
通讯作者：
Maisano, Federico
影响因子：
2.9
作者：
Bacyinski A;Xu M;Wang W;Hu J
通讯作者：
Hu J
影响因子：
6.7
作者：
Bradu, Andrei;Penescu, Mircea;Bourrinet, Philippe
通讯作者：
Bourrinet, Philippe