SARS-CoV-2 Seropositivity in Asymptomatic Frontline Health Workers in Ibadan, Nigeria.
SARS-CoV-2 Seropositivity in Asymptomatic Frontline Health Workers in Ibadan, Nigeria.
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DOI：
10.4269/ajtmh.20-1235
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发表时间：
2021-01
期刊：
影响因子：
--
通讯作者：
Awah N
中科院分区：
文献类型：
--
作者：
Olayanju O;Bamidele O;Edem F;Eseile B;Amoo A;Nwaokenye J;Udeh C;Oluwole G;Odok G;Awah N
COVID-19大流行使全球卫生陷入动荡，在世界几乎所有大洲造成了毁灭性的发病率和前所未有的生命损失。据预测，由于卫生结构差和生活条件极其恶劣，非洲大流行病的严重程度将很高，但令人惊讶的是，这种情况并未发生。据推测，年轻的人群和强大的免疫系统具有保护作用，许多人可能接触过这种病毒，但没有患上严重的疾病。他们中的大多数人会在医院出现其他疾病，并可能在无意中将COVID-19传播给卫生工作者。本研究旨在测量卫生工作者血清SARS-CoV-2 IgG水平，作为潜在暴露的标志。从尼日利亚伊巴丹大学学院医院随机抽取无症状一线卫生工作者；采集静脉血，ELISA法检测血清SARS-CoV-2 IgG水平。获得了血清阳性参与者的比例，并确定了与血清阳性相关的因素。该研究共招募了133名参与者，其中60人（45.1%）的SARS-CoV-2血清阳性。血清阳性的参与者包括医生、护士、卫生助理、实验室科学家和技术人员以及非医务人员。产科、妇科和急诊科血清阳性的几率较高。尽管无症状，但一线卫生工作者中SARS-CoV-2的血清阳性率非常高。这要求采取更严格的预防措施，防止在医院环境内进一步传播。
Global health has been thrown into turmoil by the COVID-19 pandemic, which has caused devastating morbidity and unprecedented loss of life in almost all continents of the world. It was predicted that the magnitude of the pandemic in Africa will be high because of poor health structure and intensely poor living condition, but that has not happened, surprisingly. It was hypothesized that the youthful population and a vastly primed immune system were protective, and many people may have been exposed without coming down with the severe disease. Most of them would have presented in hospitals with other medical conditions and possibly transmit COVID-19 to health workers inadvertently. This study is designed to measure serum SARS-CoV-2 IgG levels in health workers as a marker of latent exposure. Asymptomatic frontline health workers were randomly selected from the University College Hospital Ibadan, Nigeria; venous blood samples were obtained from them, and the serum SARS-CoV-2 IgG level was determined using ELISA techniques. A proportion of participants with seropositivity were obtained, and factors associated with seropositivity were determined. A total of 133 participants were recruited for this study, and 60 (45.1%) of them were seropositive for SARS-CoV-2. Among the seropositive participants were doctors, nurses, health assistants, laboratory scientists and technicians, and nonmedical staff. Obstetrics, gynecology, and emergency departments had higher odds of seropositivity. Seroprevalence of SARS-CoV-2 is very high among frontline health workers, though asymptomatic. This calls for a more stringent precaution against further spread within the hospital environment.
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DOI：
10.1111/j.1469-0691.2005.01081.x
发表时间：
2005-04
期刊：
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
影响因子：
--
作者：
Cantón R
通讯作者：
Cantón R
影响因子：
9.8
作者：
Ceylan, Zeynep
通讯作者：
Ceylan, Zeynep
影响因子：
19
作者：
Fischer, Bastian;Knabbe, Cornelius;Vollmer, Tanja
通讯作者：
Vollmer, Tanja
影响因子：
168.9
作者：
Pollan, Marina;Perez-Gomez, Beatriz;Yotti, Raquel
通讯作者：
Yotti, Raquel
影响因子：
13.2
作者：
Lone, Shabir Ahmad;Ahmad, Aijaz
通讯作者：
Ahmad, Aijaz