Cytoplasmic microtubule organization in fission yeast.

Cytoplasmic microtubule organization in fission yeast.
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DOI:
10.1002/yea.1404
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发表时间:
2006-10-15
期刊:
Yeast (Chichester, England)
影响因子:
--
通讯作者:
Tran PT
Tran PT
中科院分区:
其他
文献类型:
--
作者:
Sawin KE;Tran PT

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在裂殖酵母粟酒裂殖酵母(Schizosaccharomyces pombe)的细胞周期中,细胞质微管细胞骨架的组织发生显著变化。这些变化可作为一种模型,用于理解分化的高等真核细胞常具有的不同微管组织模式。在过去几年中,我们对裂殖酵母细胞质微管的组织和行为的理解取得了相当大的进展,不仅在相关基因和蛋白质的鉴定方面,而且在利用体内荧光标记蛋白质对功能进行生理分析方面也是如此。在这篇综述中,我们从三个方面讨论我们的知识现状:微管成核、微管动力学的调控以及微管束的组织和极性。这些方面的进展为更详细地理解细胞质微管组织提供了一个坚实的框架。
During the cell cycle of the fission yeast Schizosaccharomyces pombe, striking changes in the organization of the cytoplasmic microtubule cytoskeleton take place. These may serve as a model for understanding the different modes of microtubule organization that are often characteristic of differentiated higher eukaryotic cells. In the last few years, considerable progress has been made in our understanding of the organization and behavior of fission yeast cytoplasmic microtubules, not only in the identification of the genes and proteins involved but also in the physiological analysis of function using fluorescently-tagged proteins in vivo. In this review we discuss the state of our knowledge in three areas: microtubule nucleation, regulation of microtubule dynamics and the organization and polarity of microtubule bundles. Advances in these areas provide a solid framework for a more detailed understanding of cytoplasmic microtubule organization.
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