A Darwinian perspective on tumor immune evasion.
A Darwinian perspective on tumor immune evasion.
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DOI：
10.1016/j.bbcan.2021.188671
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发表时间：
2022-01
期刊：
影响因子：
--
通讯作者：
Polyak K
中科院分区：
文献类型：
--
作者：
Puleo J;Polyak K
Evading immune-mediated destruction is a critical step of tumor evolution and the immune system is one of the strongest selective pressures during tumorigenesis. Analyzing tumor immune evasion from a Darwinian perspective may provide critical insight into the mechanisms of primary immune escape and acquired resistance to immunotherapy. Here, we review the steps required to mount an anti-tumor immune response, describe how each of these steps is disrupted during tumorigenesis, list therapeutic strategies to restore anti-tumor immunity, and discuss each mechanism of immune and therapeutic evasion from a Darwinian perspective.
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