Contribution of low population immunity to the severe Omicron BA.2 outbreak in Hong Kong.
Contribution of low population immunity to the severe Omicron BA.2 outbreak in Hong Kong.
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DOI：
10.1038/s41467-022-31395-0
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发表时间：
2022-06-24
影响因子：
16.6
通讯作者：
To, Kelvin Kai-Wang
中科院分区：
文献类型：
--
作者：
Chen, Lin-Lei;Abdullah, Syed Muhammad Umer;Chan, Wan-Mui;Chan, Brian Pui-Chun;Ip, Jonathan Daniel;Chu, Allen Wing-Ho;Lu, Lu;Zhang, Xiaojuan;Zhao, Yan;Chuang, Vivien Wai-Man;Au, Albert Ka-Wing;Cheng, Vincent Chi-Chung;Sridhar, Siddharth;Yuen, Kwok-Yung;Hung, Ivan Fan-Ngai;Chan, Kwok-Hung;To, Kelvin Kai-Wang
监测人群对SARS-CoV-2变异株的保护性免疫对于风险评估至关重要。我们假设香港在2022年初爆发的Omicron BA.2疫情可以用低群体免疫力来解释。我们使用2021年1月至12月收集的血清进行的血清阳性率研究显示，老年人中抗祖先病毒的中和抗体（NAb）的流行率非常低。NAb的年龄组特异性患病率通常与疫苗接种率相关，但老年人的NAb血清阳性率远低于疫苗接种率。在所有年龄组别中，NAb对Omicron变种的血清阳性率远低于对祖先病毒的血清阳性率。我们的研究表明，这次BA.2暴发和≥80岁年龄组异常高的病死率（9.2%）可归因于人群中缺乏保护性免疫力，特别是在脆弱的老年人中，持续的血清监测至关重要。香港于2022年初经历严重的SARS-CoV-2疫情。在这里，作者使用基因组和血清监测数据，并表明这一波是由Omicron BA.2亚系占主导地位，低保护性免疫，特别是在老年群体中，导致其严重性。
Monitoring population protective immunity against SARS-CoV-2 variants is critical for risk assessment. We hypothesize that Hong Kong’s explosive Omicron BA.2 outbreak in early 2022 could be explained by low herd immunity. Our seroprevalence study using sera collected from January to December 2021 shows a very low prevalence of neutralizing antibodies (NAb) against ancestral virus among older adults. The age group-specific prevalence of NAb generally correlates with the vaccination uptake rate, but older adults have a much lower NAb seropositive rate than vaccination uptake rate. For all age groups, the seroprevalence of NAb against Omicron variant is much lower than that against the ancestral virus. Our study suggests that this BA.2 outbreak and the exceptionally high case-fatality rate in the ≥80 year-old age group (9.2%) could be attributed to the lack of protective immunity in the population, especially among the vulnerable older adults, and that ongoing sero-surveillance is essential. Hong Kong experienced a severe wave of SARS-CoV-2 in early 2022. Here, the authors use genomic and serosurveillance data and show that this wave was dominated by the Omicron BA.2 sublineage, and that low protective immunity, particularly in older age groups, contributed to its severity.
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DOI：
10.3390/diagnostics11101757
发表时间：
2021-09-24
期刊：
Diagnostics (Basel, Switzerland)
影响因子：
--
作者：
Chan KH;Leung KY;Zhang RR;Liu D;Fan Y;Chen H;Yuen KY;Hung IF
通讯作者：
Hung IF
影响因子：
13.6
作者：
Cheng VC;Lung DC;Wong SC;Au AK;Wang Q;Chen H;Xin L;Chu AW;Ip JD;Chan WM;Tsoi HW;Tse H;Ng KH;Kwan MY;Chuang SK;To KK;Li Y;Yuen KY
通讯作者：
Yuen KY
影响因子：
168.9
作者：
Chan, Jasper Fuk-Woo;Yuan, Shuofeng;Yuen, Kwok-Yung
通讯作者：
Yuen, Kwok-Yung
DOI：
10.1126/science.abm3425
发表时间：
2022-01-07
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
通讯作者：
--
DOI：
10.1016/s2666-5247(21)00305-0
发表时间：
2022-04
期刊：
The Lancet. Microbe
影响因子：
--
作者：
Barin B;Kasap U;Selçuk F;Volkan E;Uluçkan Ö
通讯作者：
Uluçkan Ö