Outbreak investigation of airborne transmission of Omicron (B.1.1.529) - SARS-CoV-2 variant of concern in a restaurant: Implication for enhancement of indoor air dilution.
Outbreak investigation of airborne transmission of Omicron (B.1.1.529) - SARS-CoV-2 variant of concern in a restaurant: Implication for enhancement of indoor air dilution.
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DOI：
10.1016/j.jhazmat.2022.128504
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发表时间：
2022-05-15
影响因子：
13.6
通讯作者：
Yuen KY
中科院分区：
文献类型：
--
作者：
Cheng VC;Lung DC;Wong SC;Au AK;Wang Q;Chen H;Xin L;Chu AW;Ip JD;Chan WM;Tsoi HW;Tse H;Ng KH;Kwan MY;Chuang SK;To KK;Li Y;Yuen KY
在COVID-19爆发期间，人们越来越认识到SARS-CoV-2的空气传播，特别是欧米克隆变体。我们调查了一家餐厅发生的欧米克隆变异病毒爆发事件。在进行流行病学和系统发育分析的基础上，比较了强化室内空气稀释前（疫情R1）和强化室内空气稀释后（疫情R2）餐厅相关疫情的顾客二次发病率。2021年12月27日，一名指示病例在R2餐厅停留98分钟。除了1个坐在同一张桌子上，其他6个次要案例分别坐在3个不同区域的3个角落，由不同的工作人员服务。中位暴露时间34 min（范围19 ~ 98 min）。7例继发性病例均与该指数有亲缘关系。烟雾试验表明，气流方向可以解释继发性病例的分布。与之前发生在强制加强室内空气稀释之前的另一家餐厅R1（2021年2月19日）的COVID-19疫情相比，R2的顾客二次发病率显著低于R1 （3.4%, 7/207 vs 28.9%, 22/76, p<0.001）。通过通风和安装空气净化器加强室内空气稀释，可以最大限度地降低餐馆传播SARS-CoV-2的风险。
Airborne transmission of SARS-CoV-2 has been increasingly recognized in the outbreak of COVID-19, especially with the Omicron variant. We investigated an outbreak due to Omicron variant in a restaurant. Besides epidemiological and phylogenetic analyses, the secondary attack rates of customers of restaurant-related COVID-19 outbreak before (Outbreak R1) and after enhancement of indoor air dilution (Outbreak R2) were compared. On 27th December 2021, an index case stayed in restaurant R2 for 98 min. Except for 1 sitting in the same table, six other secondary cases sat in 3 corners at 3 different zones, which were served by different staff. The median exposure time was 34 min (range: 19–98 min). All 7 secondary cases were phylogenetically related to the index. Smoke test demonstrated that the airflow direction may explain the distribution of secondary cases. Compared with an earlier COVID-19 outbreak in another restaurant R1 (19th February 2021), which occurred prior to the mandatory enhancement of indoor air dilution, the secondary attack rate among customers in R2 was significantly lower than that in R1 (3.4%, 7/207 vs 28.9%, 22/76, p<0.001). Enhancement of indoor air dilution through ventilation and installation of air purifier could minimize the risk of SARS-CoV-2 transmission in the restaurants.
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影响因子：
12.7
作者：
Ito, Kimihito;Piantham, Chayada;Nishiura, Hiroshi
通讯作者：
Nishiura, Hiroshi
影响因子：
11.8
作者：
Cheng, Vincent Chi-Chung;Fung, Kitty Sau-Chun;Yuen, Kwok-Yung
通讯作者：
Yuen, Kwok-Yung
影响因子：
10.7
作者：
Nguyen LT;Schmidt HA;von Haeseler A;Minh BQ
通讯作者：
Minh BQ
影响因子：
10.7
作者：
Katoh K;Standley DM
通讯作者：
Standley DM
DOI：
10.1093/cid/ciaa1558
发表时间：
2021-07-30
期刊：
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
影响因子：
--
作者：
Fung HF;Martinez L;Alarid-Escudero F;Salomon JA;Studdert DM;Andrews JR;Goldhaber-Fiebert JD;Stanford-CIDE Coronavirus Simulation Model (SC-COSMO) Modeling Group
通讯作者：
Stanford-CIDE Coronavirus Simulation Model (SC-COSMO) Modeling Group