Changing epidemiology of pulmonary nontuberculous mycobacteria infections.

Changing epidemiology of pulmonary nontuberculous mycobacteria infections.
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DOI:
10.3201/eid1610.091201
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发表时间:
2010-10
影响因子:
11.8
通讯作者:
NTM working group at Queensland TB Control Centre and Queensland Mycobacterial Reference Laboratory
NTM working group at Queensland TB Control Centre and Queensland Mycobacterial Reference Laboratory
中科院分区:
医学2区
文献类型:
--
作者:
Thomson RM;NTM working group at Queensland TB Control Centre and Queensland Mycobacterial Reference Laboratory

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非结核分枝杆菌 (NTM) 疾病是澳大利亚昆士兰州的一种应通报疾病。需要进行物种鉴定的分枝杆菌分离株被转发至昆士兰分枝杆菌参考实验室,为获取全州 NTM 疾病流行病学数据提供了中心机会。我们比较了 1999 年和 2005 年获得的分离株,并使用昆士兰通知计划的数据来报告这些分离株的临床相关性。通报的具有临床意义的肺部疾病病例的发病率从每 10 万人 2.2 例(1999 年)上升到 3.2 例(2005 年)。疾病模式已从吸烟的中年男性的主要空洞性疾病转变为老年女性的纤维结节性疾病。胞内分枝杆菌是与昆士兰分离株增加相关的主要病原体。
Nontuberculous mycobacteria (NTM) disease is a notifiable condition in Queensland, Australia. Mycobacterial isolates that require species identification are forwarded to the Queensland Mycobacterial Reference Laboratory, providing a central opportunity to capture statewide data on the epidemiology of NTM disease. We compared isolates obtained in 1999 and 2005 and used data from the Queensland notification scheme to report the clinical relevance of these isolates. The incidence of notified cases of clinically significant pulmonary disease rose from 2.2 (1999) to 3.2 (2005) per 100,000 population. The pattern of disease has changed from predominantly cavitary disease in middle-aged men who smoke to fibronodular disease in elderly women. Mycobacterium intracellulare is the main pathogen associated with the increase in isolates speciated in Queensland.
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