Receptor tyrosine kinase signaling: regulating neural crest development one phosphate at a time.
Receptor tyrosine kinase signaling: regulating neural crest development one phosphate at a time.
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DOI：
10.1016/bs.ctdb.2014.11.005
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发表时间：
2015
影响因子：
--
通讯作者：
Soriano, Philippe
中科院分区：
文献类型：
--
作者：
Fantauzzo, Katherine A.;Soriano, Philippe
受体酪氨酸激酶（RTKs）与细胞表面的一组生长因子结合，并在发育和出生后的细胞过程中引发广泛的反应。该亚类受体包括胞外配体结合结构域、单个跨膜结构域和胞内结构域，其中包含催化酪氨酸激酶和可被受体本身或各种相互作用蛋白磷酸化的调控序列。一旦激活，RTKs结合信号分子并招募效应蛋白，通过各种细胞内信号通路介导下游细胞反应。在本章中，我们将重点介绍RTK家族的一个子集在哺乳动物系统中调节神经嵴细胞（NCCs）的活性及其衍生物的发展中的作用。NCCs是一种可迁移的多能细胞，可细分为四个轴向群体：颅、心、迷走神经和躯干。这些细胞沿着确定的途径在脊椎动物胚胎中迁移，并产生独特的细胞类型和结构。有趣的是，单个RTK家族通常在ncc亚群中具有特定功能，这有助于这些细胞及其衍生物在哺乳动物胚胎中的多样性。我们还将讨论目前用于研究RTK信号传导的方法，包括遗传、生化、大规模蛋白质组学和生物传感器方法，这些方法可用于研究NCC发育过程中该受体亚类下游活跃的细胞内信号通路。
Receptor tyrosine kinases (RTKs) bind to a subset of growth factors on the surface of cells and elicit responses with broad roles in developmental and postnatal cellular processes. Receptors in this subclass consist of an extracellular ligand-binding domain, a single transmembrane domain, and an intracellular domain harboring a catalytic tyrosine kinase and regulatory sequences that are phosphorylated either by the receptor itself or various interacting proteins. Once activated, RTKs bind signaling molecules and recruit effector proteins to mediate downstream cellular responses through various intracellular signaling pathways. In this chapter, we will highlight the role of a subset of RTK families in regulating the activity of neural crest cells (NCCs) and the development of their derivatives in mammalian systems. NCCs are migratory, multipotent cells that can be subdivided into four axial populations, cranial, cardiac, vagal and trunk. These cells migrate throughout the vertebrate embryo along defined pathways and give rise to unique cell types and structures. Interestingly, individual RTK families often have specific functions in a subpopulation of NCCs that contribute to the diversity of these cells and their derivatives in the mammalian embryo. We will additionally discuss current methods used to investigate RTK signaling, including genetic, biochemical, large-scale proteomic and biosensor approaches, which can be applied to study intracellular signaling pathways active downstream of this receptor subclass during NCC development.
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DOI：
10.1016/0167-4838(87)90112-9
发表时间：
1987-11-26
期刊：
BIOCHIMICA ET BIOPHYSICA ACTA
影响因子：
--
作者：
BAJAJ, M;WATERFIELD, MD;BLUNDELL, T
通讯作者：
BLUNDELL, T
影响因子：
56.9
作者：
Bruckner, K;Pasquale, EB;Klein, R
通讯作者：
Klein, R
影响因子：
56.9
作者：
BOTTARO, DP;RUBIN, JS;AARONSON, SA
通讯作者：
AARONSON, SA
影响因子：
30.8
作者：
Afzal, AR;Rajab, A;Jeffery, S
通讯作者：
Jeffery, S
影响因子：
3.5
作者：
AVIVI, A;YAYON, A;GIVOL, D
通讯作者：
GIVOL, D