Associations of psychological wellbeing with COVID-19 hospitalization and mortality in adults aged 50 years or older from 25 European countries and Israel.

Associations of psychological wellbeing with COVID-19 hospitalization and mortality in adults aged 50 years or older from 25 European countries and Israel.
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DOI:
10.3389/fpubh.2023.1124915
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发表时间:
2023
影响因子:
5.2
通讯作者:
Dang, Shuangsuo
Dang, Shuangsuo
中科院分区:
医学3区
文献类型:
--
作者:
Wang, Wenjun;Wang, Jingjing;Shi, Juanjuan;Li, Yaping;Zhang, Xin;Wu, Fengping;Wang, Yikai;Li, Jia;Hao, Miao;Liu, Xiongtao;Zhai, Song;Wang, Yuan;Gao, Ning;Tian, Yan;Lu, Rui;Yeo, Yee Hui;Jia, Xiaoli;Ji, Fanpu;Dang, Shuangsuo

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在各种疾病和健康人群中,较低的心理幸福感与不良结局有关。然而,还没有研究调查心理健康是否与新冠肺炎的结果相关。这项研究旨在确定心理幸福感较低的个体是否更有可能患上新冠肺炎不良结局。数据来自2017年欧洲健康、老龄化和退休调查(SHARE)和SHARE在2020年6-9月和2021年6-8月的两次新冠肺炎调查。2017年使用CASP-12量表测量心理幸福感。采用Logistic模型对年龄、性别、体重指数、吸烟、体力活动、家庭收入、教育水平和慢性病进行校正,评估CASP12评分与新冠肺炎住院和死亡率的关系。敏感性分析是通过输入缺失数据或排除仅根据症状诊断新冠肺炎的病例进行的。使用英语老龄化纵向研究(ELSA)的数据进行了验证性分析。数据分析发生在2022年10月。总共有来自25个欧洲国家和以色列的3886名50岁或50岁以上的新冠肺炎患者入院治疗,其中580人住院(14.9%),100人死亡(2.6%)。与CASP12评分中三位数(最高)相比,新冠肺炎住院调整的OR值分别为1.81(95%CI,1.41~2.31)和1.37(95%CI,1.07~1.75)。至于新冠肺炎死亡率,调整OR值分别为2.05(95%CI,1.12~3.77)和1.78(95%CI,0.98~3.23)。与三分位数3相比,结果对丢失数据或仅根据症状排除病例相对稳健。在ELSA中也观察到CASP-12评分与新冠肺炎住院风险之间的负关联。这项研究表明,在50岁或以上的欧洲成年人中,较低的心理幸福感与新冠肺炎住院风险和死亡率的增加独立相关。需要进一步的研究,以在最近和未来的新冠肺炎大流行浪潮和其他人群中验证这些关联。
Lower psychological wellbeing is associated with poor outcomes in a variety of diseases and healthy populations. However, no study has investigated whether psychological wellbeing is associated with the outcomes of COVID-19. This study aimed to determine whether individuals with lower psychological wellbeing are more at risk for poor outcomes of COVID-19. Data were from the Survey of Health, Aging, and Retirement in Europe (SHARE) in 2017 and SHARE's two COVID-19 surveys in June–September 2020 and June–August 2021. Psychological wellbeing was measured using the CASP-12 scale in 2017. The associations of the CASP-12 score with COVID-19 hospitalization and mortality were assessed using logistic models adjusted for age, sex, body mass index, smoking, physical activity, household income, education level, and chronic conditions. Sensitivity analyses were performed by imputing missing data or excluding cases whose diagnosis of COVID-19 was solely based on symptoms. A confirmatory analysis was conducted using data from the English Longitudinal Study of Aging (ELSA). Data analysis took place in October 2022. In total, 3,886 individuals of 50 years of age or older with COVID-19 were included from 25 European countries and Israel, with 580 hospitalized (14.9%) and 100 deaths (2.6%). Compared with individuals in tertile 3 (highest) of the CASP-12 score, the adjusted odds ratios (ORs) of COVID-19 hospitalization were 1.81 (95% CI, 1.41–2.31) for those in tertile 1 (lowest) and 1.37 (95% CI, 1.07–1.75) for those in tertile 2. As for COVID-19 mortality, the adjusted ORs were 2.05 (95% CI, 1.12–3.77) for tertile 1 and 1.78 (95% CI, 0.98–3.23) for tertile 2, compared with tertile 3. The results were relatively robust to missing data or the exclusion of cases solely based on symptoms. This inverse association of the CASP-12 score with COVID-19 hospitalization risk was also observed in ELSA. This study shows that lower psychological wellbeing is independently associated with increased risks of COVID-19 hospitalization and mortality in European adults aged 50 years or older. Further study is needed to validate these associations in recent and future waves of the COVID-19 pandemic and other populations.
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