Parental age and childhood cancer risk: A Danish population-based registry study.
Parental age and childhood cancer risk: A Danish population-based registry study.
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DOI：
10.1016/j.canep.2017.06.010
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发表时间：
2017-08
影响因子：
2.6
通讯作者：
Heck JE
中科院分区：
文献类型：
--
作者：
Contreras ZA;Hansen J;Ritz B;Olsen J;Yu F;Heck JE
虽然父母在孩子出生时的年龄与儿童癌症风险之间的关联以前已经被研究过，但迄今为止的证据是不确定的，并且对于罕见的癌症类型是稀缺的。癌症病例（N= 5，856）选自1968-2014年出生并于1968-2015年在丹麦诊断的所有儿童，年龄小于16岁，在全国丹麦癌症登记处列出。病例按性别和出生年份与对照组（1：100）进行个体匹配，从丹麦中央人口登记处（Danish Central Population Registry）的丹麦所有活产婴儿中随机抽取了585，594例对照组。父母在孩子出生时的年龄是从中央人口登记处提取的。条件logistic回归模型被用来估计儿童出生时父母年龄与儿童癌症风险之间关系的比值比。父母年龄被建模为分类（参考组，父母年龄为25-29岁）和连续每5年的年龄增长。高龄母亲的后代患急性淋巴细胞白血病（ALL）的风险增加[OR=1.10，95%CI：（1.02，1.19）每5岁增加]。高龄产妇（40岁以上）患非霍奇金淋巴瘤（NHL）的风险增加[OR=1.96，95%CI：（1.12，3.43）]。随着父亲年龄的增加，肾母细胞瘤的风险也增加[OR=1.11，95%CI：（0.97，1.28）/5岁]。父母年龄较大是丹麦儿童各种儿童癌症的危险因素。进一步调查的生物和社会因素，可能有助于这些协会是必要的。
Though the association between parental age at child’s birth and the risk of childhood cancer has been previously investigated, the evidence to date is inconclusive and scarce for rarer cancer types. Cancer cases (N=5,856) were selected from all children born from 1968–2014 and diagnosed from 1968–2015 in Denmark at less than 16 years of age listed in the nationwide Danish Cancer Registry. Cases were individually matched to controls (1:100) on sex and year of birth with a total of 585,594 controls randomly sampled from all live births in Denmark from the Danish Central Population Registry. Parental age at child’s birth was extracted from the Central Population Registry. Conditional logistic regression models were used to estimate odds ratios for the association between parental age at child’s birth and childhood cancer risk. Parental age was modeled as both categorical (referent group, parents aged 25–29) and continuous per 5-year increase in age. Offspring of older mothers were at an increased risk of acute lymphoblastic leukemia (ALL) [OR=1.10, 95% CI: (1.02, 1.19) per 5-year increase in age]. Older maternal age (40+) increased the risk of non-Hodgkin lymphoma (NHL) [OR=1.96, 95%CI: (1.12, 3.43)]. The risk of Wilms’ tumor also appeared elevated with older paternal age [OR=1.11, 95% CI: (0.97, 1.28) per 5-year increment in age]. Older parental age was a risk factor for various childhood cancers in Danish children. Further investigation of the biological and social factors that may be contributing to these associations is warranted.
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影响因子：
12.3
作者：
Acuna-Hidalgo R;Veltman JA;Hoischen A
通讯作者：
Hoischen A
影响因子：
5.3
作者：
Dryja, TP;Morrow, JF;Rapaport, JM
通讯作者：
Rapaport, JM
影响因子：
6.4
作者：
Hargreave, Marie;Jensen, Allan;Deltour, Isabelle;Brinton, Louise A.;Andersen, Klaus K.;Kjaer, Susanne K.
通讯作者：
Kjaer, Susanne K.
影响因子：
2.6
作者：
Heck, Julia E.;Meyers, Travis J.;Lombardi, Christina;Park, Andrew S.;Cockburn, Myles;Reynolds, Peggy;Ritz, Beate
通讯作者：
Ritz, Beate
影响因子：
2.3
作者：
Ajrouche, Roula;Rudant, Jeremie;Clavel, Jacqueline
通讯作者：
Clavel, Jacqueline