A large N400 but no BOLD effect--comparing source activations of semantic priming in simultaneous EEG-fMRI.
A large N400 but no BOLD effect--comparing source activations of semantic priming in simultaneous EEG-fMRI.
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DOI：
10.1371/journal.pone.0084029
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Dobel C
中科院分区：
文献类型：
--
作者：
Geukes S;Huster RJ;Wollbrink A;Junghöfer M;Zwitserlood P;Dobel C
许多研究报道了脑电图（EEG）和功能磁共振成像（fMRI）中语义启动的神经生理学效应。由于不同的方法限制，观察到的效果的可比性仍不清楚。为了直接比较脑电图和功能磁共振成像的效果以及语义启动的神经源，我们在同时测量脑电图和功能磁共振成像的同时进行了语义词-图片启动实验。视觉呈现的素数是伪词、与目标无关的词、语义相关的词以及与目标相同的名称。事件相关电位 (ERP) 的分布式源分析成功揭示了语义主要目标相关性的巨大影响（N400 效应），这是由左颞源区域的激活驱动的。然而，在功能磁共振成像数据中没有发现启动条件之间的激活存在显着差异。我们的结果支持这样的观点，即为了联合解释现有的语义启动脑电图和功能磁共振成像研究，我们需要充分认识各自的方法学局限性。其次，他们表明同步 EEG-fMRI（包括 ERP 源定位）对于研究更高认知过程来说是一种可行且有前途的方法论进步。第三，他们证实了这一发现，即与功能磁共振成像相比，ERP 通常对微妙的认知效应更敏感。
Numerous studies have reported neurophysiological effects of semantic priming in electroencephalography (EEG) and in functional magnetic resonance imaging (fMRI). Because of differing methodological constraints, the comparability of the observed effects remains unclear. To directly compare EEG and fMRI effects and neural sources of semantic priming, we conducted a semantic word-picture priming experiment while measuring EEG and fMRI simultaneously. The visually presented primes were pseudowords, words unrelated to the target, semantically related words and the identical names of the target. Distributed source analysis of the event-related potentials (ERPs) successfully revealed a large effect of semantic prime-target relatedness (the N400 effect), which was driven by activations in a left-temporal source region. However, no significantly differing activations between priming conditions were found in the fMRI data. Our results support the notion that, for joint interpretations of existing EEG and fMRI studies of semantic priming, we need to fully appreciate the respective methodological limitations. Second, they show that simultaneous EEG-fMRI, including ERP source localization, is a feasible and promising methodological advancement for the investigation of higher-cognitive processes. Third, they substantiate the finding that, compared to fMRI, ERPs are often more sensitive to subtle cognitive effects.
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