Ras controls growth, survival and differentiation in the Drosophila eye by different thresholds of MAP kinase activity.
Ras controls growth, survival and differentiation in the Drosophila eye by different thresholds of MAP kinase activity.
复制标题
Ras 通过不同的 MAP 激酶活性阈值控制果蝇眼的生长、存活和分化。
作者：
Kristine Halfar;Christian Rommel;Hugo Stocker;E. Hafen
Ras在发育过程中介导过多的细胞功能。在果蝇发育中的眼睛中，Ras执行三个时间上独立的功能。在分裂的细胞中，它是生长所必需的，但对细胞周期进程不是必需的。在有丝分裂后的细胞中，它促进小眼细胞的存活和随后的分化。在本文中，我们通过使用分子定义的Ras完全和部分功能丧失突变来分析Ras在眼睛发育过程中的不同作用。我们发现，Ras的三种不同功能是由MAPK活性的不同阈值介导的。低MAPK活性抑制细胞存活并允许R8感光细胞分化，而高或持续的MAPK活性足以在分裂细胞中过早诱导R1-R7感光细胞分化。
Ras mediates a plethora of cellular functions during development. In the developing eye of Drosophila, Ras performs three temporally separate functions. In dividing cells, it is required for growth but is not essential for cell cycle progression. In postmitotic cells, it promotes survival and subsequent differentiation of ommatidial cells. In the present paper, we have analyzed the different roles of Ras during eye development by using molecularly defined complete and partial loss-of-function mutations of Ras. We show that the three different functions of Ras are mediated by distinct thresholds of MAPK activity. Low MAPK activity prolongs cell survival and permits differentiation of R8 photoreceptor cells while high or persistent MAPK activity is sufficient to precociously induce R1-R7 photoreceptor differentiation in dividing cells.
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线虫外阴诱导过程中需要 Hox 基因 lin-39 来选择 Ras 信号传导的结果。
DOI：
10.1242/dev.125.2.181
发表时间：
1998
期刊：
Development (Cambridge, England)
影响因子：
--
作者：
Maloof,JN;Kenyon,C
通讯作者：
Kenyon,C
影响因子：
3.3
作者：
Jon D. Schnorr;C. Berg
通讯作者：
Jon D. Schnorr;C. Berg
影响因子：
4.6
作者：
T. Wolff;D. Ready
通讯作者：
T. Wolff;D. Ready
影响因子：
56.9
作者：
Montagne, J;Stewart, MJ;Thomas, G
通讯作者：
Thomas, G