S100A11 is required for efficient plasma membrane repair and survival of invasive cancer cells.
S100A11 is required for efficient plasma membrane repair and survival of invasive cancer cells.
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DOI：
10.1038/ncomms4795
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发表时间：
2014-05-08
影响因子：
16.6
通讯作者：
Nylandsted, Jesper
中科院分区：
文献类型：
--
作者：
Jaiswal, Jyoti K.;Lauritzen, Stine P.;Scheffer, Luana;Sakaguchi, Masakiyo;Bunkenborg, Jakob;Simon, Sanford M.;Kallunki, Tuula;Jaattela, Marja;Nylandsted, Jesper
细胞迁移和侵袭需要增加质膜动力学和穿越致密基质的能力，从而使质膜暴露在巨大的物理压力下。然而，转移性癌细胞如何获得应对这种压力的能力在很大程度上是未知的。本研究表明，S100A11是一种钙结合蛋白，在多种转移性癌症中上调，对高效的质膜修复和高运动癌细胞的存活至关重要。质膜损伤诱导的钙进入细胞触发S100A11和膜联蛋白A2向损伤部位募集。我们发现，与膜联蛋白A2复合物中的S100A11通过促进皮质f -肌动蛋白的聚合和切除受损的质膜部分来帮助重新封闭质膜。这些数据揭示了质膜修复，特别是S100A11和膜联蛋白A2，是治疗转移性癌症的新靶点。
Cell migration and invasion require increased plasma membrane dynamics and ability to navigate through dense stroma, thereby exposing plasma membrane to tremendous physical stress. Yet, it is largely unknown how metastatic cancer cells acquire an ability to cope with such stress. Here we show that S100A11, a calcium-binding protein up-regulated in a variety of metastatic cancers, is essential for efficient plasma membrane repair and survival of highly motile cancer cells. Plasma membrane injury-induced entry of calcium into the cell triggers recruitment of S100A11 and Annexin A2 to the site of injury. We show that S100A11 in a complex with Annexin A2 helps reseal the plasma membrane by facilitating polymerization of cortical F-actin and excision of the damaged part of the plasma membrane. These data reveal plasma membrane repair in general and S100A11 and Annexin A2 in particular, as new targets for the therapy of metastatic cancers.
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影响因子：
11.4
作者：
Hayes, Matthew J.;Shao, Dongmin;Moss, Stephen E.
通讯作者：
Moss, Stephen E.
影响因子：
5.8
作者：
Draeger, Annette;Monastyrskaya, Katia;Babiychuk, Eduard B.
通讯作者：
Babiychuk, Eduard B.
影响因子：
1.2
作者：
Defour, Aurelia;Sreetama, S. C.;Jaiswal, Jyoti K.
通讯作者：
Jaiswal, Jyoti K.
结肠衍生的肝转移，结直肠癌和肝细胞癌可以通过Ca（2+） - 结合蛋白S100A6和S100A11区分。
影响因子：
3.7
作者：
Melle, Christian;Ernst, Guenther;Schimmel, Bettina;Bleul, Annett;von Eggeling, Ferdinand
通讯作者：
von Eggeling, Ferdinand
影响因子：
7.7
作者：
Howard AC;McNeil AK;Xiong F;Xiong WC;McNeil PL
通讯作者：
McNeil PL