The Assessment of the Osteoporosis Self-Assessment Tool for Asians and Calcaneal Quantitative Ultrasound in Identifying Osteoporotic Fractures and Falls Among Chinese People.
The Assessment of the Osteoporosis Self-Assessment Tool for Asians and Calcaneal Quantitative Ultrasound in Identifying Osteoporotic Fractures and Falls Among Chinese People.
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亚洲人骨质疏松自我评估工具和跟骨定量超声在识别中国人骨质疏松性骨折和跌倒方面的评估
DOI：
10.3389/fendo.2021.684334
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发表时间：
2021
影响因子：
5.2
通讯作者：
Yue H
中科院分区：
文献类型：
--
作者：
Gao C;Song H;Chen B;Zhang Z;Yue H
由于DXA的缺乏，在中国广大的农村地区，骨质疏松症的诊断和治疗变得非常困难，农村地区是骨质疏松症高危人群最多的地区。本横断面研究的目的是评价亚洲人骨质疏松自我评估工具（OSTA）和跟骨定量超声（QUS）在中国上海人群中的相关性，以及它们在预测骨质疏松性骨折和福尔斯方面的评估。收集了12，033名参与者，包括1272名男性（平均年龄68.3 ± 9.8岁，范围28-100岁）和10，761名女性（平均年龄56.8 ± 11.4岁，范围23-99岁）。测量OSTA和跟骨QUS（Sonost 2000，OsteoSys）值。使用斯皮尔曼相关性和科恩kappa来确定OSTA和QUS之间的关联和一致性。受试者工作特征（ROC）曲线适用于评估OSTA和QUS在骨质疏松性骨折和跌倒筛查中的性能和最佳截止值。总的来说，女性中脊椎骨折（低创伤骨折，包括脊柱、髋关节、前臂、肱骨和肋骨骨折）的患病率为15.2%，17.7%的女性报告有福尔斯史（过去一年中从站立高度跌倒超过一次）。有相同病史的男性比例分别为8.4%和11.7%。OSTA与QUS之间的相关性为rs = 0.393，κ = 0.137，p < 0.001。OSTA（临界值<-1）显示，在识别具有QUS定义的中度或高度骨质疏松风险的女性个体（T评分<-1）时，ROC曲线下面积（AUC）为0.590。绝经后妇女的QUS T评分低于-1.55或-1.40可能分别导致福尔斯或桡骨骨折的风险增加。QUS和OSTA之间的协议似乎是有限的，在确定个人的骨质疏松症的风险。双能X线骨密度仪（DXA）测定骨密度（BMD）在骨质疏松症的临床诊断中仍有必要。OSTA和QUS T评分低于各自的临界值可能表明椎体骨折和福尔斯的风险增加，个体应接受进一步治疗和DXA筛查。
The lack of DXA has made the diagnosis and treatment of osteoporosis extremely difficult in the vast rural areas of China, which has the largest population with high risks of osteoporosis. The aims of this cross-sectional study were to evaluate the association between the osteoporosis self-assessment tool for Asians (OSTA) and calcaneus quantitative ultrasound (QUS) in populations residing in Shanghai, China, and their assessment in predicting osteoporotic fractures and falls. A population of 12,033 participants, including 1272 males (average age 68.3 ± 9.8 years, range 28–100 years) and 10,761 females (average 56.8 ± 11.4 years, range 23–99 years), was gathered. OSTA and calcaneus QUS (Sonost 2000, OsteoSys) values were measured. Spearman’s correlation and Cohen’s kappa were used to determine the association and agreement between the OSTA and QUS. Receiver operating characteristic (ROC) curves were adapted to assess the performance and optimal cutoff values for the OSTA and QUS in osteoporotic fracture and fall screening. In total, the prevalence of osteoporotic fractures (low-trauma fractures including fractures of the spine, hip, forearm, humerus and ribs) was 15.2% in women, and 17.7% reported a history of falls (falling from standing height more than once in the past year). The percentages of men with the same history were 8.4% and 11.7%, respectively. The association between the OSTA and QUS was found to be rs = 0.393, κ = 0.137, p < 0.001. The OSTA (cutoff < −1) revealed an area under ROC curve (AUC) of 0.590 in identifying female individuals with moderate or high risk of osteoporosis defined by QUS (T-score < −1). The QUS T-score lower than −1.55 or −1.40 in postmenopausal women may lead to an increased risk of falls or osteoporotic fractures, respectively. The agreement between QUS and the OSTA seemed to be limited in determining individuals at risk of osteoporosis. Measuring bone mineral density (BMD) by dual energy X-ray absorptiometry (DXA) may still be necessary in the clinical diagnosis of osteoporosis. OSTA and QUS T-scores less than the respective cutoff values may indicate an increased risk of osteoporotic fractures and falls that individual should be further treated and screened by DXA.
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影响因子：
4
作者：
Hans, D;Hartl, F;Krieg, MA
通讯作者：
Krieg, MA
影响因子：
6.2
作者：
Hans, Didier;Durosier, Claire;Krieg, Marc-Antoine
通讯作者：
Krieg, Marc-Antoine
影响因子：
2.8
作者：
Chin KY;Low NY;Kamaruddin AAA;Dewiputri WI;Soelaiman IN
通讯作者：
Soelaiman IN
影响因子：
4.1
作者：
Thomsen K;Ryg J;Hermann AP;Matzen L;Masud T
通讯作者：
Masud T
影响因子：
5.7
作者：
Diem, Susan J.;Peters, Katherine W.;Ensrud, Kristine E.
通讯作者：
Ensrud, Kristine E.