Serotonergic neurons translate taste detection into internal nutrient regulation.
Serotonergic neurons translate taste detection into internal nutrient regulation.
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DOI：
10.1016/j.neuron.2021.12.028
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发表时间：
2022-03-16
期刊：
影响因子：
16.2
通讯作者：
Scott K
中科院分区：
文献类型：
--
作者：
Yao Z;Scott K
神经系统和内分泌系统协调监测和调节营养物质的供应，以维持能量稳态。食物的感官检测以预期食物摄入的方式调节内部营养物质的可用性，但促进预期生理变化的感官途径仍不清楚。在这里，我们确定了多巴胺能（5-HT）神经元的关键介质，转换味觉检测的感觉神经元的胰岛素产生细胞和肠道神经元的激活在果蝇。一类5-HT神经元对糖的味觉检测做出反应，兴奋胰岛素产生细胞，并限制消费，这表明它们预期营养水平增加并防止过度消费。第二类5-HT神经元响应苦味化合物的味觉检测，并激活肠神经元以促进胃运动，可能刺激消化并在食物排斥时增加循环营养。这些研究表明，5-羟色胺神经元中继急性味觉检测到不同的途径，长期稳定的循环营养物质。Yao和Scott在果蝇中发现了两类不同的5-HT神经元，它们对味觉检测做出反应，并预先调节摄食、内分泌和消化功能。这项工作提供了深入了解5-HT子电路的不同功能和营养物质稳态的预期调节的神经基础。
The nervous and endocrine systems coordinately monitor and regulate nutrient availability to maintain energy homeostasis. Sensory detection of food regulates internal nutrient availability in a manner that anticipates food intake, but sensory pathways that promote anticipatory physiological changes remain unclear. Here, we identify serotonergic (5-HT) neurons as critical mediators that transform gustatory detection by sensory neurons into the activation of insulin-producing cells and enteric neurons in Drosophila. One class of 5-HT neurons responds to gustatory detection of sugars, excites insulin-producing cells, and limits consumption, suggesting that they anticipate increased nutrient levels and prevent overconsumption. A second class of 5-HT neurons responds to gustatory detection of bitter compounds and activates enteric neurons to promote gastric motility, likely to stimulate digestion and increase circulating nutrients upon food rejection. These studies demonstrate that 5-HT neurons relay acute gustatory detection to divergent pathways for longer-term stabilization of circulating nutrients. Yao and Scott discover two distinct classes of serotonergic (5-HT) neurons in Drosophila that respond to taste detection and preemptively regulate feeding and endocrine and digestive function. This work provides insight into the diverse functions of 5-HT sub-circuits and the neural basis for anticipatory regulation of nutrient homeostasis.
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DOI：
10.1002/bies.201500167
发表时间：
2016-04
期刊：
BioEssays : news and reviews in molecular, cellular and developmental biology
影响因子：
--
作者：
Chen Y;Knight ZA
通讯作者：
Knight ZA
影响因子：
5.7
作者：
Freeman EG;Dahanukar A
通讯作者：
Dahanukar A
影响因子：
64.8
作者：
Augustine V;Gokce SK;Lee S;Wang B;Davidson TJ;Reimann F;Gribble F;Deisseroth K;Lois C;Oka Y
通讯作者：
Oka Y
影响因子：
16.2
作者：
Bidaye, Salil S.;Laturney, Meghan;Chang, Amy K.;Liu, Yuejiang;Bockemuehl, Till;Bueschges, Ansgar;Scott, Kristin
通讯作者：
Scott, Kristin
影响因子：
64.8
作者：
FISCHER, JA;GINIGER, E;PTASHNE, M
通讯作者：
PTASHNE, M