A novel oral nutritional supplement improves gait speed and mitochondrial functioning compared to standard care in older adults with (or at risk of) undernutrition: results from a randomized controlled trial.
A novel oral nutritional supplement improves gait speed and mitochondrial functioning compared to standard care in older adults with (or at risk of) undernutrition: results from a randomized controlled trial.
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DOI：
10.18632/aging.202912
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发表时间：
2021-04-02
期刊：
影响因子：
--
通讯作者：
Groot L
中科院分区：
文献类型：
--
作者：
Grootswagers P;Smeets E;Oteng AB;Groot L
老年人营养不良主要通过口服营养补充剂解决，这种补充剂不影响身体机能。在这项研究中，我们测试了一种新的口服营养补充剂，其中包括乳清和酪蛋白，熊果酸，游离支链氨基酸和维生素D对标准补充剂。我们纳入了营养不良（或有营养不良风险）的老年人（> 65岁）（n=82），并将他们随机分配至12周的新型或标准补充剂。两组的体重都有显著增加。未观察到瘦体重的组内或组间差异。标准组的脂肪量增加显著高于新型补充剂组（时间 * 治疗效果P=0.045）。与标准治疗组相比，新型补充剂组在4 m（治疗x时间相互作用P=0.048）和400 m（治疗x时间相互作用P=0.038）距离上的行走性能改善更大。与线粒体功能和氧化磷酸化相关的基因组在新补充剂组中上调，在标准补充剂组中下调。我们的结论是，与标准补充剂相比，使用新型补充剂进行12周的干预改善了短距离和长距离的行走性能，这在很大程度上可以通过接受新型补充剂的组中线粒体功能的增加来解释。
Undernutrition in older adults is mainly addressed by oral nutritional supplements, which do not affect physical functioning. In this study, we tested a novel oral nutritional supplement that included whey and casein protein, ursolic acid, free branch-chained amino acids and vitamin D against a standard supplement. We included older adults (>65y) with (or at risk of) undernutrition (n=82) and randomized them to 12 weeks of novel or standard supplement. Both groups showed significant increases in body mass. No within or between-group differences in lean body mass were observed. Fat mass increased significantly more in the standard than the novel supplement group (time*treatment effect P=0.045). The novel supplement group showed a larger improvement in walking performance on distances of 4m (treatment x time interaction P=0.048) and 400m (treatment x time interaction P=0.038) than the standard treatment group. Gene sets related to mitochondrial functioning and oxidative phosphorylation were upregulated in the novel supplement group and downregulated in the standard supplement group. We conclude that a 12-week intervention with the novel supplement improved walking performance both during short and long distance as compared to a standard supplement, which can largely be explained by increased mitochondrial functioning in the group receiving the novel supplement.
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影响因子：
29
作者：
Kunkel SD;Suneja M;Ebert SM;Bongers KS;Fox DK;Malmberg SE;Alipour F;Shields RK;Adams CM
通讯作者：
Adams CM
影响因子：
4
作者：
Fusco, Oriana;Ferrini, Alessandro;Cesari, Matteo
通讯作者：
Cesari, Matteo
DOI：
10.1016/j.jamda.2015.05.021
发表时间：
2015-09-01
影响因子：
7.6
作者：
Bauer, Juergen M.;Verlaan, Sjors;Cederholm, Tommy
通讯作者：
Cederholm, Tommy
DOI：
10.1002/jcsm.12272
发表时间：
2018-04
期刊：
Journal of cachexia, sarcopenia and muscle
影响因子：
--
作者：
Distefano G;Standley RA;Zhang X;Carnero EA;Yi F;Cornnell HH;Coen PM
通讯作者：
Coen PM
影响因子：
6.3
作者：
Hubbard, Gary P.;Elia, Marinos;Stratton, Rebecca J.
通讯作者：
Stratton, Rebecca J.