Decreasing ascorbate intake does not affect the levels of glutathione, tocopherol or retinol in the ascorbate-requiring osteogenic disorder shionogi rats.
Decreasing ascorbate intake does not affect the levels of glutathione, tocopherol or retinol in the ascorbate-requiring osteogenic disorder shionogi rats.
复制标题
减少抗坏血酸摄入量不会影响需要抗坏血酸的成骨性疾病 shionogi 大鼠中谷胱甘肽、生育酚或视黄醇的水平。
DOI：
10.1093/jn/129.6.1229
复制
发表时间：
1999
期刊：
影响因子：
--
通讯作者：
A. Taylor
中科院分区：
文献类型：
--
作者：
D. Smith;F. Shang;T. Nowell;G. Asmundsson;G. Perrone;G. Dallal;L. Scott;M. Kelliher;B. Gindelsky;A. Taylor
对饲喂半纯化饮食的雄性和雌性需要抗坏血酸的成骨性疾病 Shionogi (ODS) 大鼠进行肝脏和肾脏中的谷胱甘肽以及血浆中其他营养素的水平评估，其中抗坏血酸的浓度从 1965 年逐渐降低至 180 mg/kg。当饮食中的抗坏血酸水平从 1965 年降低到 768 mg/kg 时，ODS 大鼠的血浆抗坏血酸水平不受影响。然而，当饮食中的抗坏血酸水平从 527 毫克/公斤减少到 180 毫克/公斤时，血浆抗坏血酸水平逐渐下降。当膳食抗坏血酸浓度从 1965 年降至 180 mg/kg 时，血浆抗坏血酸水平下降达 77%。当膳食抗坏血酸水平从 1965 年降低到 180 毫克/公斤时，肝脏和肾脏中的抗坏血酸水平下降了 60-70%。然而，这些组织中的谷胱甘肽水平并未受到影响。血浆视黄醇和维生素 E 水平不受膳食抗坏血酸摄入量减少的影响。随着膳食抗坏血酸摄入量的下降，雌性大鼠的总胆固醇水平显着升高。当膳食抗坏血酸水平从 1965 年降至 527 毫克/公斤时，糖化血红蛋白水平显着下降。这项研究表明，在非坏血酸条件下，维生素 E、视黄醇和谷胱甘肽的水平不受抗坏血酸膳食摄入量减少的影响，而抗坏血酸摄入量的增加与雌性 ODS 大鼠血浆胆固醇水平的降低有关。然而，过量摄入抗坏血酸可能与血红蛋白糖化升高有关。为了实现抗坏血酸补充剂的最大健康益处，需要进一步研究来确定最佳抗坏血酸摄入量。
Levels of glutathione in liver and kidney, and other nutrients in plasma were evaluated in male and female ascorbate-requiring osteogenic disorder Shionogi (ODS) rats fed semipurified diets in which the concentrations of ascorbate were gradually decreased from 1965 to 180 mg/kg. Plasma ascorbate levels in ODS rats were unaffected when ascorbate levels in the diet were decreased from 1965 to 768 mg/kg. However, plasma ascorbate levels decreased progressively when levels of ascorbate in the diet were decreased from 527 to 180 mg/kg. Plasma ascorbate levels decreased up to 77% when the dietary ascorbate concentration decreased from 1965 to 180 mg/kg. Ascorbate levels in liver and kidney fell as much as 60-70% when the dietary ascorbate levels were reduced from 1965 to 180 mg/kg. However, the glutathione levels in these tissues were not affected. Plasma retinol and vitamin E levels were not affected by decreasing dietary ascorbate intake. Total cholesterol levels increased significantly in female rats as dietary ascorbate intake declined. Levels of glycated hemoglobin decreased significantly when dietary ascorbate levels decreased from 1965 to 527 mg/kg. This study suggests that levels of vitamin E, retinol and glutathione are not affected by decreased dietary intake of ascorbate under nonscorbutic conditions, whereas elevated ascorbate intake is associated with a decrease in levels of plasma cholesterol in female ODS rats. However, excessive intake of ascorbate may be associated with elevated glycation of hemoglobin. To achieve the maximal health benefit of ascorbate supplementation, further studies are necessary to define optimal ascorbate intakes.
抗坏血酸诱导的晶状体蛋白交联：支持美拉德反应的证据。
DOI：
10.1016/0167-4838(88)90292-0
发表时间：
1988
期刊：
Biochimica et biophysica acta
影响因子：
--
作者：
Ortwerth,BJ;Olesen,PR
通讯作者：
Olesen,PR
人和豚鼠房水、晶状体和血浆中的维生素 C 与摄入量的关系。
影响因子：
2
作者：
Taylor,A;Jacques,PF;Nowell,T;Perrone,G;Blumberg,J;Handelman,G;Jozwiak,B;Nadler,D
通讯作者：
Nadler,D
DOI：
10.1073/pnas.88.11.4656
发表时间：
1991-06-01
影响因子：
11.1
作者：
MRTENSSON, J;MEISTER, A
通讯作者：
MEISTER, A