Vitamin C in human and guinea pig aqueous, lens and plasma in relation to intake.
Vitamin C in human and guinea pig aqueous, lens and plasma in relation to intake.
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人和豚鼠房水、晶状体和血浆中的维生素 C 与摄入量的关系。
DOI：
10.1076/ceyr.16.9.857.5039
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发表时间：
1997
影响因子：
2
通讯作者：
Nadler,D
中科院分区：
文献类型：
--
作者：
Taylor,A;Jacques,PF;Nowell,T;Perrone,G;Blumberg,J;Handelman,G;Jozwiak,B;Nadler,D
考虑到最近营养与眼病风险之间的相关性，人们对营养摄入与眼组织营养水平之间可能的相关性非常感兴趣。在这项工作中，目的是（1）首次确定维生素C的饮食摄入量与自由生活的人类中维生素C的眼组织水平之间的关系，（2）确定血浆、透镜和房水中维生素C水平之间的关系，和（3）将这些信息与一组精心饲养的豚鼠收集的数据进行比较，这些豚鼠被喂食不同水平的维生素C。本研究招募了来自临床实践的5名白内障患者（平均年龄= 72岁）。132例患者通过食物频率问卷提供了饮食摄入数据，我们将其用于这项工作。在晶状体切除术时获得血浆、房水和透镜样本，并保存用于维生素C分析。从喂食已知量维生素C的雄性Hartley白色豚鼠中获得可比样本。线性和log 10-线性统计模型也被用于描述维生素C摄入量和人眼组织维生素水平之间的关系，并检查潜在的混杂和年龄和性别的影响。斜率为0.03 mM血浆维生素C/log 10 mg每日维生素C摄入量和0.41 mM水性维生素C/log 10 mg每日维生素C摄入量。透镜和饮食中维生素C水平的最佳拟合预测了线性关系，性别调整斜率为0.00094 mM透镜维生素C/mg每日维生素C摄入量，尽管也可以建模对数线性关系。在豚鼠中，饮食与眼组织和血浆维生素水平相关，在所有情况下均呈log 10线性关系。人透镜中的维生素C与血浆和水溶液中的维生素C呈线性相关，斜率分别为8.8和0.23。水溶液中的维生素C与血浆以log 10线性方式相关，斜率为1.6 mM水溶液维生素C/log 10 mM血浆维生素C。在豚鼠中，血浆中的维生素C与水和透镜维生素C的对数10线性关系，而透镜和水的维生素C.CONCLUSIONSPlasma和水似乎是饱和的人摄入量< 250毫克维生素C/天。然而，本研究并未表明人类透镜维生素C与膳食摄入量之间存在饱和关系，尽管在豚鼠中观察到了这种关系。人类和豚鼠维生素C水平之间的组织间关系在某些方面是相似的，但不是所有的关系。
PURPOSEGiven the recent correlation between nutrition and risk for eye disease, there is keen interest in a possible correlation between nutrient intake and eye-tissue nutrient levels. In this work, the objective was (1) to determine, for the first time, the relation between dietary intake of vitamin C and eye tissue levels of the vitamin in free-living humans, (2) to determine the relation between levels of the vitamin in plasma, lens and aqueous, and (3) to compare this information to data gathered for a carefully reared group of guinea pigs that were fed different levels of vitamin C.METHODSTwo hundred sixty-five cataract patients (mean age = 72 years) from a clinical practice were recruited for this study. One hundred thirty-two patients provided the dietary intake data via a food frequency questionnaire, which we used for this work. Plasma, aqueous humor, and lens samples were obtained at the time of lentectomy and preserved for vitamin C analysis. Comparable samples were obtained from male Hartley white guinea pigs that were fed known amounts of vitamin C. Linear and log10-linear statistical models were also used to characterize the relation between vitamin C intake and human ocular-tissue levels of the vitamin and to examine potential confounding and the effect of modification by age and sex.RESULTSIn humans, plasma and aqueous vitamin C concentrations were related to intake in a log-linear fashion, with slopes of 0.03 mM plasma vitamin C/log 10 -mg daily vitamin C intake and 0.41 mM aqueous vitamin C/log 10 -mg daily vitamin C intake. The best fit of vitamin C levels in lens and diet predicts a linear relationship with a sex-adjusted slope of 0.00094 mM lens vitamin C/mg daily vitamin C intake, although a log-linear relation can also be modeled. In guinea pigs, diet was related to eye tissue and plasma levels of the vitamin by a log 10 linear relationship in all cases. Vitamin C in human lens was linearly related to plasma and aqueous vitamin C with slopes of 8.8 and 0.23, respectively. Vitamin C in aqueous was related to plasma in a log 10 -linear fashion with a slope of 1.6 mM aqueous vitamin C/log 10 mM plasma vitamin C. In guinea pigs, vitamin C in plasma was related to aqueous and lens vitamin C by log 10 -linear relationships, whereas lens and aqueous vitamin C were clearly linearly related.CONCLUSIONSPlasma and aqueous appear to be saturated in humans with intakes of < 250 mg vitamin C/day. However, a saturating relationship between lens vitamin C and dietary intake in humans was not indicated in this study, although such a relationship is seen in guinea pigs. Intertissue relations between vitamin C levels in humans and guinea pigs are similar for some but not all relations.
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影响因子：
5
作者：
KAHN, HA;LEIBOWITZ, HM;DAWBER, TR
通讯作者：
DAWBER, TR
影响因子：
13.7
作者：
B. Klein;R. Klein;K. L. Linton
通讯作者：
B. Klein;R. Klein;K. L. Linton
老年性白内障与抗坏血酸负荷
影响因子：
3.4
作者：
A. Ringvold;H. Johnsen;S. Blika
通讯作者：
S. Blika
患有和不患有白内障的患者的房水和血清中的抗坏血酸；
DOI：
10.1001/archopht.1954.00920040003001
发表时间：
1954
期刊：
A.M.A. archives of ophthalmology
影响因子：
--
作者：
E. Purcell;L. H. Lerner;V. Kinsey
通讯作者：
V. Kinsey
影响因子：
2
作者：
BERGER, J;SHEPHARD, D;TAYLOR, A
通讯作者：
TAYLOR, A