Observer repeatability and interscan reproducibility of 18F-sodium fluoride coronary microcalcification activity.
Observer repeatability and interscan reproducibility of 18F-sodium fluoride coronary microcalcification activity.
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DOI：
10.1007/s12350-020-02221-1
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发表时间：
2022-03
期刊：
影响因子：
--
通讯作者：
Slomka PJ
中科院分区：
文献类型：
--
作者：
Tzolos E;Kwiecinski J;Lassen ML;Cadet S;Adamson PD;Moss AJ;Joshi N;Williams MC;van Beek EJR;Dey D;Berman DS;Dweck MR;Newby DE;Slomka PJ
我们的目的是建立冠状动脉18f -氟化钠正电子发射断层扫描（PET）摄取的观察者可重复性和扫描间可重复性，使用一种新的半自动方法，冠状动脉微钙化活性（CMA）。多支冠状动脉疾病患者接受多次PET和CTA混合成像（PET/CTA）。CMA定义为整个冠状树的综合标准化摄取值（SUV）超过背景SUV 2个标准差。在血管和患者水平上确定同一观察者之间（观察者内重复性）、两个观察者之间（观察者间重复性）和两次扫描之间的重复性系数（扫描间重复性）。在19例患者中，在相隔12±5天的两次PET/CT扫描中，对43条冠状动脉进行了两次CMA评估。观察者内重复性、观察者间重复性和扫描间重复性均有极好的类内相关性（均≥0.991）。对于冠状动脉18f - naf摄取存在（CMA=0）或不存在（CMA=0），观察者内、观察者间和扫描间的一致性为100%。所有测量的平均CMA为3.12±0.62，重复性系数≤10%：在每个血管和每个患者水平上，观察者内分别为0.24和0.22，观察者间分别为0.30和0.29，扫描间分别为0.33和0.32。CMA是冠状动脉粥样硬化活动的可重复和可再现的全球测量。
We aimed to establish the observer repeatability and interscan reproducibility of coronary 18F-sodium-fluoride positron emission tomography (PET) uptake using, a novel semi-automated approach, coronary microcalcification activity (CMA). Patients with multivessel coronary artery disease underwent repeated hybrid PET and computed tomography angiography (CTA) imaging (PET/CTA). CMA was defined as the integrated standardized uptake values (SUV) in the entire coronary tree exceeding 2 standard deviations above the background SUV. Coefficients of repeatability between the same observer (intraobserver repeatability), between 2 observers (interobserver repeatability) and coefficient of reproducibility between 2 scans (interscan reproducibility), were determined at vessel and patient level. In 19 patients, CMA was assessed twice in 43 coronary vessels on two PET/CT scans performed 12±5 days apart. There was excellent intraclass correlation for intraobserver and interobserver repeatability as well as interscan reproducibility (all ≥0.991). There was 100% intraobserver, interobserver and interscan agreement for the presence (CMA>0) or absence (CMA=0) of coronary18F-NaF uptake. Mean CMA was 3.12±0.62 with coefficients of repeatability of ≤10% for all measures: intraobserver 0.24 and 0.22, interobserver 0.30 and 0.29 and interscan 0.33 and 0.32 at a per-vessel and per-patient level respectively. CMA is a repeatable and reproducible global measure of coronary atherosclerotic activity.
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影响因子：
24
作者：
Erbel, Raimund;Moehlenkamp, Stefan;Joeckel, Karl-Heinz
通讯作者：
Joeckel, Karl-Heinz
DOI：
10.1016/0735-1097(90)90282-t
发表时间：
1990-03-15
影响因子：
24
作者：
AGATSTON, AS;JANOWITZ, WR;DETRANO, R
通讯作者：
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作者：
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通讯作者：
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影响因子：
39.3
作者：
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通讯作者：
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影响因子：
24
作者：
Greenland P;Blaha MJ;Budoff MJ;Erbel R;Watson KE
通讯作者：
Watson KE