Tensile properties and fiber alignment of human supraspinatus tendon in the transverse direction demonstrate inhomogeneity, nonlinearity, and regional isotropy.
Tensile properties and fiber alignment of human supraspinatus tendon in the transverse direction demonstrate inhomogeneity, nonlinearity, and regional isotropy.
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DOI：
10.1016/j.jbiomech.2009.10.017
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发表时间：
2010-03-03
影响因子：
2.4
通讯作者：
Soslowsky, Louis J.
中科院分区：
文献类型：
--
作者：
Lake, Spencer P.;Miller, Kristin S.;Elliott, Dawn M.;Soslowsky, Louis J.
关键词：
最近的一项研究报告了沿主要纤维方向测试的人类冈上肌腱 (SST) 的特性。研究发现，SST 的胶原纤维分布相对分散，这可能代表了对肩袖复杂负载环境所施加的多轴负载的适应。然而，人类 SST 的多轴力学特性仍然未知。因此，本研究的目的是评估横向测试中 SST 的机械性能、纤维排列、排列随施加载荷的变化以及 SST 的结构功能关系。来自六个 SST 位置的样品在单轴拉伸下进行了测试，样品横向于肌腱长轴。偏振光成像用于量化胶原纤维排列和施加负载下排列的变化。与关节表面相比，在腱骨插入点附近采集的样品的机械性能在法氏囊表面上要大得多（例如，法氏囊模量比关节大 15-30 倍；p<0.001）。事实上，法氏囊样本的横向模量值与沿肌腱长轴测试的样本获得的值非常相似（Lake 等人，In press，JOR）。这一关键且意外的发现表明，插入附近的法氏囊表面样本具有平面机械各向同性，这可能是由于复杂的体内负载所致。在组织上，在应力应变响应的脚趾区域，纤维分布沿着肌腱长轴变得不太对齐。线性区域中发生的排列变化程度稍小，表明胶原纤维的运动可能在机械非线性中发挥作用。横向机械性能与纤维排列显着相关（例如，线性区域模量 rs=0.74，p<0.0001），表现出很强的结构-功能关系。这些结果极大地增强了目前对人类 SST 特性的理解，并为临床医生和科学家尝试治疗或替换这种复杂组织提供了重要信息。
A recent study reported the properties of human supraspinatus tendon (SST) tested along the predominant fiber direction. The SST was found to have a relatively disperse distribution of collagen fibers, which may represent an adaptation to multiaxial loads imposed by the complex loading environment of the rotator cuff. However, the multiaxial mechanical properties of human SST remain unknown. The objective of this study, therefore, was to evaluate the mechanical properties, fiber alignment, change in alignment with applied load, and structure-function relationships of SST in transverse testing. Samples from six SST locations were tested in uniaxial tension with samples oriented transverse to the tendon long-axis. Polarized light imaging was used to quantify collagen fiber alignment and change in alignment under applied load. The mechanical properties of samples taken near the tendon-bone insertion were much greater on the bursal surface compared to the joint surface (e.g., bursal moduli 15–30 times greater than joint; p<0.001). In fact, the transverse moduli values of the bursal samples were very similar to values obtained from samples tested along the tendon long-axis (Lake et al., In press, JOR). This key and unexpected finding suggests planar mechanical isotropy for bursal surface samples near the insertion, which may be due to complex in vivo loading. Organizationally, fiber distributions became less aligned along the tendon long-axis in the toe-region of the stress-strain response. Alignment changes occurred to a slightly lesser degree in the linear-region, suggesting that movement of collagen fibers may play a role in mechanical nonlinearity. Transverse mechanical properties were significantly correlated with fiber alignment (e.g., for linear-region modulus rs=0.74, p<0.0001), demonstrating strong structure-function relationships. These results greatly enhance current understanding of the properties of human SST and provide clinicians and scientists with vital information in attempting to treat or replace this complex tissue.
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影响因子：
1.9
作者：
CARLSON, GD;BOTTE, MJ;WOO, SLY
通讯作者：
WOO, SLY
DOI：
10.1115/1.1427698
发表时间：
2002-02-01
影响因子：
1.7
作者：
Hansen, KA;Weiss, JA;Barton, JK
通讯作者：
Barton, JK
影响因子：
--
作者：
Morgan, Mary;Kostyuk, Oksana;Mudera, Vivek
通讯作者：
Mudera, Vivek
影响因子：
2.8
作者：
Lake, Spencer P.;Miller, Kristin S.;Elliott, Dawn M.;Soslowsky, Louis J.
通讯作者：
Soslowsky, Louis J.
影响因子：
2.4
作者：
BUTLER, DL;GROOD, ES;BRACKETT, K
通讯作者：
BRACKETT, K