The Role of Cell Adhesion Molecule 1 (CADM1) in Cutaneous Malignancies.
The Role of Cell Adhesion Molecule 1 (CADM1) in Cutaneous Malignancies.
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细胞粘附分子1 （CADM1）在皮肤恶性肿瘤中的作用。
DOI：
10.3390/ijms21249732
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发表时间：
2020-12-20
影响因子：
5.6
通讯作者：
Nakamura M
中科院分区：
文献类型：
--
作者：
Sawada Y;Mashima E;Saito-Sasaki N;Nakamura M
细胞粘附能力是建立细胞组织的组成部分之一，并对由各种类型的细胞混合物组成的人体结构显示出巨大的贡献，以协调组织特异性功能。细胞粘附分子1（CADM 1）是一种具有多种功能的细胞粘附分子，已被鉴定为肿瘤抑制基因。CADM 1在恶性肿瘤的发病机制中具有多种功能，并与其他正常细胞如免疫细胞密切相关。然而，关于CADM 1在皮肤细胞和皮肤恶性肿瘤中的功能知之甚少。CADM 1在细胞相互连接，接触细胞以传递信号，以及作为其他免疫细胞的支架分子以发展其免疫反应方面起着重要作用。有限数量的研究揭示了CADM 1对皮肤恶性肿瘤发展的贡献。皮肤鳞状细胞癌和恶性黑色素瘤等实体性皮肤恶性肿瘤通过降低CADM 1的表达促进肿瘤的侵袭和转移。与除了默克尔细胞癌之外的这些皮肤实体瘤相反，皮肤淋巴瘤，例如成人T细胞白血病/淋巴瘤、蕈样肉芽肿和Sézary综合征，增加它们的CADM 1表达以促进肿瘤环境的发展。基于CADM 1在肿瘤发生中的作用，CADM 1的贡献理论将被期望应用于皮肤肿瘤，根据其他器官恶性肿瘤，但是，皮肤作为一个多组分外周器官的特性应该记住来总结它们的分类。
Cell adhesion ability is one of the components to establish cell organization and shows a great contribution to human body construction consisting of various types of cells mixture to orchestrate tissue specific function. The cell adhesion molecule 1 (CADM1) is a molecule of cell adhesion with multiple functions and has been identified as a tumor suppressor gene. CADM1 has multifunctions on the pathogenesis of malignancies, and other normal cells such as immune cells. However, little is known about the function of CADM1 on cutaneous cells and cutaneous malignancies. CADM1 plays an important role in connecting cells with each other, contacting cells to deliver their signal, and acting as a scaffolding molecule for other immune cells to develop their immune responses. A limited number of studies reveal the contribution of CADM1 on the development of cutaneous malignancies. Solid cutaneous malignancies, such as cutaneous squamous cell carcinoma and malignant melanoma, reduce their CADM1 expression to promote the invasion and metastasis of the tumor. On the contrary to these cutaneous solid tumors except for Merkel cell carcinoma, cutaneous lymphomas, such as adult-T cell leukemia/lymphoma, mycosis fungoides, and Sézary syndrome, increase their CADM1 expression for the development of tumor environment. Based on the role of CADM1 in the etiology of tumor development, the theory of CADM1 contribution will desirably be applied to skin tumors according to other organ malignancies, however, the characteristics of skin as a multicomponent peripheral organ should be kept in mind to conclude their prognoses.
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影响因子：
7.8
作者：
Furuse, Mikio;Hata, Masaki;Furuse, Kyoko;Yoshida, Yoko;Haratake, Akinori;Sugitani, Yoshinobu;Noda, Tetsuo;Kubo, Akiharu;Tsukita, Shoichiro
通讯作者：
Tsukita, Shoichiro
影响因子：
5.4
作者：
Dewan, M. Zahidunnabi;Takamatsu, Naofumi;Morishita, Kazuhiro
通讯作者：
Morishita, Kazuhiro
影响因子：
56.9
作者：
Biederer, T;Sara, Y;Südhof, TC
通讯作者：
Südhof, TC
影响因子：
64.8
作者：
CRICK, F
通讯作者：
CRICK, F
影响因子：
20.3
作者：
Hasstedt, Sandra J.;Bezemer, Irene D.;Bovill, Edwin G.
通讯作者：
Bovill, Edwin G.